Gene:
MMP1
matrix metallopeptidase 1 (interstitial collagenase)

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for MMP1

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs2071230 NC_000011.10:g.102790228A>G, NC_000011.9:g.102660959A>G, NG_011740.1:g.13008T>C, NM_001145938.1:c.*184T>C, NM_002421.3:c.*184T>C, NR_038390.1:n.390-2917A>G, XM_005271555.1:c.*184T>C, rs52837546
A > G
SNP
rs7945189 NC_000011.10:g.102789833C>T, NC_000011.9:g.102660564C>T, NG_011740.1:g.13403G>A, NM_001145938.1:c.*579G>A, NM_002421.3:c.*579G>A, NR_038390.1:n.390-3312C>T, XM_005271555.1:c.*579G>A, rs17879145, rs386614267, rs59202656
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  CLG
Alternate Symbols:  None
PharmGKB Accession Id: PA30867

Details

Cytogenetic Location: chr11 : q22.3 - q22.2
GP mRNA Boundary: chr11 : 102660641 - 102668966
GP Gene Boundary: chr11 : 102657641 - 102678966
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MMP10

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
doxorubicin

Curated Information ?

Publications related to MMP1: 5

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic effects on postprandial variations of inflammatory markers in healthy individuals. Obesity (Silver Spring, Md.). 2010. Cheng Yu-Ching, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. The American journal of cardiology. 2010. St Germaine Christine G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels. Circulation. Cardiovascular genetics. 2009. Cheng Yu-Ching, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A frequent functional SNP in the MMP1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosa. Human mutation. 2008. Titeux Matthias, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance. Oncogene. 2001. Turton N J, et al. PubMed

LinkOuts

NCBI Gene:
4312
OMIM:
120353
226600
606963
UCSC Genome Browser:
NM_002421
RefSeq RNA:
NM_001145938
NM_002421
RefSeq Protein:
NP_001139410
NP_002412
RefSeq DNA:
NG_011740
NT_033899
HuGE:
MMP1
Comparative Toxicogenomics Database:
4312
ModBase:
P03956
HumanCyc Gene:
HS07652
HGNC:
7155

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