Gene:
MEG3
maternally expressed 3 (non-protein coding)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for MEG3

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs116907618 NC_000014.8:g.101324135G>C, NC_000014.9:g.100857798G>C, NG_016853.1:g.36691G>C, NR_002766.2:n.1260-2893G>C, NR_003530.2:n.1510-2893G>C, NR_003531.3:n.1377-2893G>C, NR_033358.1:n.1390-2893G>C, NR_033359.1:n.1369-2893G>C, NR_033360.1:n.1276-2893G>C, NR_046464.1:n.1324-2893G>C, NR_046465.2:n.1298-2893G>C, NR_046466.1:n.1146-2893G>C, NR_046467.1:n.1428-2893G>C, NR_046468.2:n.1390-2893G>C, NR_046469.1:n.1290-2893G>C, NR_046470.2:n.1420-2893G>C, NR_046471.1:n.1184-2893G>C, NR_046472.1:n.1314-2893G>C
G > C
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  long intergenic non-protein coding RNA 23; non-protein coding RNA 23
Alternate Symbols:  GTL2; LINC00023; NCRNA00023
PharmGKB Accession Id: PA30737

Details

Cytogenetic Location: chr14 : q32.2 - q32.2
GP mRNA Boundary: chr14 : 101292445 - 101327363
GP Gene Boundary: chr14 : 101282445 - 101330363
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Platinum compounds

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Lung Neoplasms

Publications related to MEG3: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016. Gong Wei-Jing, et al. PubMed

LinkOuts

NCBI Gene:
55384
OMIM:
605636
UCSC Genome Browser:
NM_018514
RefSeq RNA:
NR_002766
NR_003530
NR_003531
NR_033358
NR_033359
NR_033360
RefSeq DNA:
NG_016853
NT_026437
GenAtlas:
MEG3
GeneCard:
MEG3
MutDB:
MEG3
HuGE:
MEG3
Comparative Toxicogenomics Database:
55384
HumanCyc Gene:
HS11809
HGNC:
14575

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