Gene:
MAPK3
mitogen-activated protein kinase 3

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PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  PRKM3
Alternate Symbols:  ERK1; p44erk1; p44mapk
PharmGKB Accession Id: PA30622

Details

Cytogenetic Location: chr16 : p11.2 - p11.2
GP mRNA Boundary: chr16 : 30125426 - 30134630
GP Gene Boundary: chr16 : 30122426 - 30144630
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. ACE Inhibitor Pathway, Pharmacodynamics
    Model, non-tissue-specific cell displaying genes which may be involved in the ACE inhibitor pathway
  1. Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Genes involved in the pharmacodynamics of the drugs that act on the renin-angiotensin-aldosterone system.
  1. Diuretics Pathway, Pharmacodynamics
    Diagrammatic representation of candidate genes involved in the pharmacodynamics of diuretics in a stylized kidney cell.
  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.
  1. Sorafenib Pharmacodynamics
    Mechanism of action of sorafenib
  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. agrin in postsynaptic differentiation - (BioCarta via Pathway Interaction Database)
  2. angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling - (BioCarta via Pathway Interaction Database)
  3. aspirin blocks signaling pathway involved in platelet activation - (BioCarta via Pathway Interaction Database)
  4. bcr signaling pathway - (BioCarta via Pathway Interaction Database)
  5. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  6. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  7. cadmium induces dna synthesis and proliferation in macrophages - (BioCarta via Pathway Interaction Database)
  8. calcium signaling by hbx of hepatitis b virus - (BioCarta via Pathway Interaction Database)
  9. ccr3 signaling in eosinophils - (BioCarta via Pathway Interaction Database)
  10. ceramide signaling pathway - (BioCarta via Pathway Interaction Database)
  11. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  12. erk and pi-3 kinase are necessary for collagen binding in corneal epithelia - (BioCarta via Pathway Interaction Database)
  13. ERK1 activation - (Reactome via Pathway Interaction Database)
  14. erk1/erk2 mapk signaling pathway - (BioCarta via Pathway Interaction Database)
  15. fc epsilon receptor i signaling in mast cells - (BioCarta via Pathway Interaction Database)
  16. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  17. how progesterone initiates the oocyte maturation - (BioCarta via Pathway Interaction Database)
  18. human cytomegalovirus and map kinase pathways - (BioCarta via Pathway Interaction Database)
  19. igf-1 signaling pathway - (BioCarta via Pathway Interaction Database)
  20. il-2 receptor beta chain in t cell activation - (BioCarta via Pathway Interaction Database)
  21. influence of ras and rho proteins on g1 to s transition - (BioCarta via Pathway Interaction Database)
  22. inhibition of cellular proliferation by gleevec - (BioCarta via Pathway Interaction Database)
  23. keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  24. links between pyk2 and map kinases - (BioCarta via Pathway Interaction Database)
  25. mapkinase signaling pathway - (BioCarta via Pathway Interaction Database)
  26. mcalpain and friends in cell motility - (BioCarta via Pathway Interaction Database)
  27. melanocyte development and pigmentation pathway - (BioCarta via Pathway Interaction Database)
  28. multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation - (BioCarta via Pathway Interaction Database)
  29. nerve growth factor pathway (ngf) - (BioCarta via Pathway Interaction Database)
  30. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  31. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  32. phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway - (BioCarta via Pathway Interaction Database)
  33. Presenilin action in Notch and Wnt signaling - (Pathway Interaction Database NCI-Nature Curated)
  34. ras-independent pathway in nk cell-mediated cytotoxicity - (BioCarta via Pathway Interaction Database)
  35. regulation of eif-4e and p70s6 kinase - (BioCarta via Pathway Interaction Database)
  36. regulation of map kinase pathways through dual specificity phosphatases - (BioCarta via Pathway Interaction Database)
  37. regulation of splicing through sam68 - (BioCarta via Pathway Interaction Database)
  38. repression of pain sensation by the transcriptional regulator dream - (BioCarta via Pathway Interaction Database)
  39. Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  40. RNA Polymerase I Promoter Opening - (Reactome via Pathway Interaction Database)
  41. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  42. role of egf receptor transactivation by gpcrs in cardiac hypertrophy - (BioCarta via Pathway Interaction Database)
  43. role of erbb2 in signal transduction and oncology - (BioCarta via Pathway Interaction Database)
  44. role of erk5 in neuronal survival pathway - (BioCarta via Pathway Interaction Database)
  45. role of mal in rho-mediated activation of srf - (BioCarta via Pathway Interaction Database)
  46. role of ß-arrestins in the activation and targeting of map kinases - (BioCarta via Pathway Interaction Database)
  47. roles of ß arrestin dependent recruitment of src kinases in gpcr signaling - (BioCarta via Pathway Interaction Database)
  48. Signal attenuation - (Reactome via Pathway Interaction Database)
  49. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  50. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  51. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  52. sprouty regulation of tyrosine kinase signals - (BioCarta via Pathway Interaction Database)
  53. stat3 signaling pathway - (BioCarta via Pathway Interaction Database)
  54. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  55. tgf beta signaling pathway - (BioCarta via Pathway Interaction Database)
  56. tpo signaling pathway - (BioCarta via Pathway Interaction Database)
  57. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)
  58. trefoil factors initiate mucosal healing - (BioCarta via Pathway Interaction Database)

Curated Information ?

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
isoproterenol
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
sorafenib
Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Beta Blocking Agents

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Asthma
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Neoplasms

Publications related to MAPK3: 5

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer research. 2004. Wilhelm Scott M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization. The Journal of biological chemistry. 2004. Huang Jianyun, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. The Biochemical journal. 2003. Shenoy Sudha K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Pulmonary pharmacology & therapeutics. 2001. Stewart A G. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 1997. Kroll J, et al. PubMed

LinkOuts

NCBI Gene:
5595
OMIM:
601795
RefSeq RNA:
NM_001040056
NM_001109891
NM_002746
RefSeq Protein:
NP_001035145
NP_001103361
NP_002737
RefSeq DNA:
NT_010393
ALFRED:
LO073680Y
HuGE:
MAPK3
Comparative Toxicogenomics Database:
5595
ModBase:
P27361
HumanCyc Gene:
HS02421
HGNC:
6877

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