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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Symbols:||ERK1; p44erk1; p44mapk|
|PharmGKB Accession Id:||PA30622|
|Cytogenetic Location:||chr16 : p11.2 - p11.2|
|GP mRNA Boundary†:||chr16 : 30125426 - 30134630|
|GP Gene Boundary†:||chr16 : 30122426 - 30144630|
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
ACE Inhibitor Pathway, Pharmacodynamics
Model, non-tissue-specific cell displaying genes which may be involved in the ACE inhibitor pathway
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
Genes involved in the pharmacodynamics of the drugs that act on the renin-angiotensin-aldosterone system.
Diuretics Pathway, Pharmacodynamics
Diagrammatic representation of candidate genes involved in the pharmacodynamics of diuretics in a stylized kidney cell.
EGFR Inhibitor Pathway, Pharmacodynamics
Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.
Mechanism of action of sorafenib
VEGF Signaling Pathway
Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.
Publications related to MAPK3: 5
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer research. 2004. Wilhelm Scott M, et al.|
||Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization. The Journal of biological chemistry. 2004. Huang Jianyun, et al.|
||Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. The Biochemical journal. 2003. Shenoy Sudha K, et al.|
||Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Pulmonary pharmacology & therapeutics. 2001. Stewart A G.|
||The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 1997. Kroll J, et al.|