Gene:
MAP3K9
mitogen-activated protein kinase kinase kinase 9

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  MLK1
Alternate Symbols:  MEKK9; PRKE1
PharmGKB Accession Id: PA30607

Details

Cytogenetic Location: chr14 : q24.3 - q24.2
GP mRNA Boundary: chr14 : 71189243 - 71275912
GP Gene Boundary: chr14 : 71186243 - 71285912
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. p38 mapk signaling pathway - (BioCarta via Pathway Interaction Database)

Publications related to MAP3K9: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges. Pharmacogenomics. 2015. Hudson Andrew M, et al. PubMed

LinkOuts

NCBI Gene:
4293
OMIM:
600136
RefSeq RNA:
NM_033141
RefSeq Protein:
NP_149132
RefSeq DNA:
NT_026437
ALFRED:
LO019221P
HuGE:
MAP3K9
ModBase:
P80192
HumanCyc Gene:
HS11962
HGNC:
6861

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