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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Symbols: ||HsT17454; MAPKK5; MEK5|
|PharmGKB Accession Id:||PA30590|
|Cytogenetic Location:||chr15 : q23 - q23|
|GP mRNA Boundary†:||chr15 : 67835021 - 68099455|
|GP Gene Boundary†:||chr15 : 67825021 - 68102455|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
VEGF Signaling Pathway
Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.
Links to non-PharmGKB pathways.
- mapkinase signaling pathway - (BioCarta via Pathway Interaction Database)
- role of erk5 in neuronal survival pathway - (BioCarta via Pathway Interaction Database)
- Signalling to ERK5 - (Reactome via Pathway Interaction Database)
- Trk receptor signaling mediated by the MAPK pathway - (Pathway Interaction Database NCI-Nature Curated)
Publications related to MAP2K5: 2
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature genetics. 2007. Winkelmann Juliane, et al.|
||The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 1997. Kroll J, et al.|