Gene:
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  D12S370
Alternate Symbols:  TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
PharmGKB Accession Id: PA30481

Details

Cytogenetic Location: chr12 : p13.31 - p13.31
GP mRNA Boundary: chr12 : 6484534 - 6500737
GP Gene Boundary: chr12 : 6474534 - 6503737
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Busulfan Pathway, Pharmacodynamics
    Schematic representation of mechanism of action of busulfan and its metabolism.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
busulfan

Curated Information ?

Publications related to LTBR: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Altered gene expression in busulfan-resistant human myeloid leukemia. Leukemia research. 2008. Valdez Benigno C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science (New York, N.Y.). 2007. Lo James C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood. 2003. Ross Mary E, et al. PubMed

LinkOuts

NCBI Gene:
4055
OMIM:
600979
UCSC Genome Browser:
NM_002342
RefSeq RNA:
NM_002342
RefSeq Protein:
NP_002333
RefSeq DNA:
NT_009759
UniProtKB:
TNR3_HUMAN (P36941)
Ensembl:
ENSG00000111321
GenAtlas:
LTBR
GeneCard:
LTBR
MutDB:
LTBR
ALFRED:
LO053449Z
HuGE:
LTBR
Comparative Toxicogenomics Database:
4055
ModBase:
P36941
HumanCyc Gene:
HS03399
HGNC:
6718

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