PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|PharmGKB Accession Id:||PA30315|
|Cytogenetic Location:||chr2 : q21.3 - q21.3|
|GP mRNA Boundary†:||chr2 : 136545415 - 136594750|
|GP Gene Boundary†:||chr2 : 136542415 - 136604750|
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
Publications related to LCT: 6
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- DG Dosing Guideline information is available
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||Convergent adaptation of human lactase persistence in Africa and Europe. Nature genetics. 2007. Tishkoff Sarah A, et al.|
||Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. American journal of human genetics. 2006. Kuokkanen Mikko, et al.|
||T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Human molecular genetics. 2005. Lewinsky Rikke H, et al.|
||Genetic signatures of strong recent positive selection at the lactase gene. American journal of human genetics. 2004. Bersaglieri Todd, et al.|
||The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans. Annals of human genetics. 2003. Poulter M, et al.|
||Identification of a variant associated with adult-type hypolactasia. Nature genetics. 2002. Enattah Nabil Sabri, et al.|