KIT ligand

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Alternate Names:  MGF; familial progressive hyperpigmentation 2; mast cell growth factor; steel factor; stem cell factor
Alternate Symbols:  FPH2; KL-1; Kitl; SCF; SF
PharmGKB Accession Id: PA30129


Cytogenetic Location: chr12 : q22 - q21.32
GP mRNA Boundary: chr12 : 88886570 - 88974250
GP Gene Boundary: chr12 : 88883570 - 88984250
Strand: minus


UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
    Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.

External Pathways

Links to non-PharmGKB pathways.

  1. cdk regulation of dna replication - (BioCarta via Pathway Interaction Database)
  2. melanocyte development and pigmentation pathway - (BioCarta via Pathway Interaction Database)
  3. regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)
  4. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)

Publications related to KITLG: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation. American journal of human genetics. 2009. Wang Zhi-Qiang, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003. Da Silva Carla Alexandra, et al. PubMed


SCF_HUMAN (P21583)
Comparative Toxicogenomics Database:
HumanCyc Gene:

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