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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Names:||MGF; familial progressive hyperpigmentation 2; mast cell growth factor; steel factor; stem cell factor|
|Alternate Symbols: ||FPH2; KL-1; Kitl; SCF; SF|
|PharmGKB Accession Id:||PA30129|
|Cytogenetic Location:||chr12 : q22 - q21.32|
|GP mRNA Boundary†:||chr12 : 88886570 - 88974250|
|GP Gene Boundary†:||chr12 : 88883570 - 88984250|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.
Links to non-PharmGKB pathways.
- cdk regulation of dna replication - (BioCarta via Pathway Interaction Database)
- melanocyte development and pigmentation pathway - (BioCarta via Pathway Interaction Database)
- regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)
- Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
Publications related to KITLG: 2
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation. American journal of human genetics. 2009. Wang Zhi-Qiang, et al.|
||Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003. Da Silva Carla Alexandra, et al.|