Gene:
KCNQ4
potassium voltage-gated channel, KQT-like subfamily, member 4

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  DFNA2
Alternate Symbols:  Kv7.4
PharmGKB Accession Id: PA30076

Details

Cytogenetic Location: chr1 : p34.2 - p34.2
GP mRNA Boundary: chr1 : 41249684 - 41306124
GP Gene Boundary: chr1 : 41239684 - 41309124
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Celecoxib Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of celecoxib and candidate genes interacting with celecoxib and involved in the regulation of cell cycle, apoptosis and angiogenesis by celecoxib.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
celecoxib
No related diseases are available

LinkOuts

NCBI Gene:
9132
OMIM:
600101
603537
UCSC Genome Browser:
NM_004700
RefSeq RNA:
NM_004700
NM_172163
RefSeq Protein:
NP_004691
NP_751895
RefSeq DNA:
NG_008139
NT_032977
UniProtKB:
KCNQ4_HUMAN (P56696)
Ensembl:
ENSG00000117013
GenAtlas:
KCNQ4
GeneCard:
KCNQ4
MutDB:
KCNQ4
ALFRED:
LO004318Q
HuGE:
KCNQ4
Comparative Toxicogenomics Database:
9132
ModBase:
P56696
HumanCyc Gene:
HS04084
IUPHAR Receptor:
Kv7.4 (563)
HGNC:
6298

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