Gene:
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for KCNJ6

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs2070995 NC_000021.8:g.39086965T>C, NC_000021.9:g.37714662T>C, NG_029892.2:g.206732A>G, NM_002240.4:c.495A>G, NP_002231.1:p.Pro165=, XM_011529558.1:c.495A>G, XM_011529559.1:c.495A>G, XP_011527860.1:p.Pro165=, XP_011527861.1:p.Pro165=, XR_937707.1:n.-1255T>C, rs58872916
T > C
SNP
P165P
No VIP available CA VA
rs2835859 NC_000021.8:g.39018162T>C, NC_000021.9:g.37645860T>C, NG_029892.2:g.275534A>G, NM_002240.4:c.947-20376A>G, XM_011529558.1:c.947-20376A>G, XM_011529559.1:c.947-20376A>G, rs57686640
T > C
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  KCNJ7
Alternate Symbols:  BIR1; GIRK2; KATP2; Kir3.2; hiGIRK2
PharmGKB Accession Id: PA30049

Details

Cytogenetic Location: chr21 : q22.13 - q22.13
GP mRNA Boundary: chr21 : 38996778 - 39288741
GP Gene Boundary: chr21 : 38993778 - 39298741
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
fentanyl
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
methadone
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
morphine
Evidence Drug Class
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Analgesics
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
opioids

Curated Information ?

Publications related to KCNJ6: 3

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PloS one. 2015. Yoshida Kaori, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size. Pharmacogenetics and genomics. 2010. Lötsch Jörn, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery. PloS one. 2009. Nishizawa Daisuke, et al. PubMed

LinkOuts

NCBI Gene:
3763
OMIM:
600877
UCSC Genome Browser:
NM_002240
RefSeq RNA:
NM_002240
RefSeq Protein:
NP_002231
RefSeq DNA:
NT_011512
UniProtKB:
IRK6_HUMAN (P48051)
Ensembl:
ENSG00000157542
GenAtlas:
KCNJ6
GeneCard:
KCNJ6
MutDB:
KCNJ6
ALFRED:
LO003525P
HuGE:
KCNJ6
Comparative Toxicogenomics Database:
3763
ModBase:
P48051
HumanCyc Gene:
HS08220
IUPHAR Receptor:
Kir3.2 (435)
HGNC:
6267

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