PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Names:||B cell differentiation factor I; T-cell replacing factor; colony-stimulating factor, eosinophil; eosinophil differentiation factor; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5|
|Alternate Symbols: ||EDF; IL-5; TRF|
|PharmGKB Accession Id:||PA29833|
|Cytogenetic Location:||chr5 : q31.1 - q31.1|
|GP mRNA Boundary†:||chr5 : 131877136 - 131892555|
|GP Gene Boundary†:||chr5 : 131874136 - 131902555|
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.
Publications related to IL5: 4
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Could personalized management of menopause based on genomics become a reality?. Pharmacogenomics. 2016. Moyer Ann M, et al.|
||STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007. Ito Noriyuki, et al.|
||Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids. Blood. 1997. Mori A, et al.|
||Inhibition of interleukin-5 gene expression by dexamethasone. Immunology. 1992. Rolfe F G, et al.|