Gene:
IL12B
interleukin 12B

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for IL12B

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs6894567
A > G
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  IL12, subunit p40; NKSF2; cytotoxic lymphocyte maturation factor 2, p40; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; natural killer cell stimulatory factor, 40 kD subunit; natural killer cell stimulatory factor-2
Alternate Symbols:  CLMF; CLMF2; IL-12B; NKSF
PharmGKB Accession Id: PA29785

Details

Cytogenetic Location: chr5 : q31.1 - q33.1
GP mRNA Boundary: chr5 : 158741791 - 158757481
GP Gene Boundary: chr5 : 158738791 - 158767481
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. IL12-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  2. IL23-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  3. IL27-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
No related genes are available

Curated Information ?

Curated Information ?

Publications related to IL12B: 7

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study. Atherosclerosis. 2014. Postmus Iris, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding. Pharmacogenomics. 2012. Olagunju Adeniyi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Predicting response to short-acting bronchodilator medication using Bayesian networks. Pharmacogenomics. 2009. Himes Blanca E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. American journal of human genetics. 2009. Wang Kai, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nature genetics. 2009. Zhang Xue-Jun, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping. Blood. 2008. Johnson David C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The IL12B gene is associated with asthma. American journal of human genetics. 2004. Randolph Adrienne G, et al. PubMed

LinkOuts

NCBI Gene:
3593
OMIM:
161561
177900
209950
600807
UCSC Genome Browser:
NM_002187
RefSeq RNA:
NM_002187
RefSeq Protein:
NP_002178
RefSeq DNA:
NG_009618
NT_023133
UniProtKB:
IL12B_HUMAN (P29460)
Ensembl:
ENSG00000113302
GenAtlas:
IL12B
GeneCard:
IL12B
MutDB:
IL12B
ALFRED:
LO014402L
HuGE:
IL12B
Comparative Toxicogenomics Database:
3593
ModBase:
P29460
HumanCyc Gene:
HS03667
HGNC:
5970

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