Gene:
IGF1
insulin-like growth factor 1 (somatomedin C)

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for IGF1

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs2946834 NC_000012.11:g.102787814A>G, NC_000012.12:g.102394036A>G, NG_011713.1:g.91565T>C, XR_945270.1:n.582-10077A>G, XR_945271.1:n.582-10077A>G, XR_945272.1:n.582-10077A>G, XR_945273.1:n.532-10077A>G, XR_945274.1:n.258-10077A>G, XR_945275.1:n.138-10077A>G, XR_945276.1:n.110-10077A>G, XR_945277.1:n.582-10077A>G, rs17880061, rs61280983
A > G
SNP
rs6214 NC_000012.11:g.102793569C>T, NC_000012.12:g.102399791C>T, NG_011713.1:g.85810G>A, NM_000618.4:c.*2716G>A, NM_001111283.2:c.*2750G>A, NM_001111284.1:c.*2716G>A, XR_944534.1:n.5737G>A, XR_944535.1:n.5514G>A, XR_944536.1:n.5499G>A, XR_945270.1:n.582-4322C>T, XR_945271.1:n.582-4322C>T, XR_945272.1:n.582-4322C>T, XR_945273.1:n.532-4322C>T, XR_945274.1:n.258-4322C>T, XR_945275.1:n.138-4322C>T, XR_945276.1:n.110-4322C>T, XR_945277.1:n.582-4322C>T, rs17847190, rs17882460, rs3730225, rs386601958, rs60827480
C > T
SNP
rs7136446 NC_000012.11:g.102838515C>T, NC_000012.12:g.102444737C>T, NG_011713.1:g.40864G>A, NM_000618.4:c.221-25047G>A, NM_001111283.2:c.221-25047G>A, NM_001111284.1:c.173-25047G>A, NM_001111285.1:c.221-25047G>A, XM_005268835.1:c.173-25047G>A, XM_005268836.1:c.152-25047G>A, XR_944534.1:n.480-25047G>A, XR_944535.1:n.257-25047G>A, XR_944536.1:n.242-25047G>A, XR_945270.1:n.6686-17991C>T, XR_945271.1:n.5739-17991C>T, XR_945272.1:n.6686-11050C>T, XR_945273.1:n.6636-17991C>T, XR_945274.1:n.6362-17991C>T, XR_945275.1:n.6242-17991C>T, XR_945276.1:n.6214-17991C>T, XR_945277.1:n.2310-17991C>T, rs17728283, rs386607780, rs60425451
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  IGF-I; IGF1A; IGFI
PharmGKB Accession Id: PA29697

Details

Cytogenetic Location: chr12 : q23.2 - q23.2
GP mRNA Boundary: chr12 : 102789645 - 102875563
GP Gene Boundary: chr12 : 102786645 - 102885563
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to IGF1: 9

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations. Journal of translational medicine. 2016. Cocca Massimiliano, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes. PloS one. 2015. Walford Geoffrey A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of anti-platelet therapy focused on peripheral blood cells of coronary arterial disease patients. Clinica chimica acta; international journal of clinical chemistry. 2013. Luchessi André Ducati, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen. The pharmacogenomics journal. 2013. Winder T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature genetics. 2012. Manning Alisa K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effects of genetic variants previously associated with fasting glucose and insulin in the diabetes prevention program. PloS one. 2012. Florez Jose C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Growth hormone pharmacogenetics: the interactive effect of a microsatellite in the IGF1 promoter region with the GHR-exon 3 and -202 A/C IGFBP3 variants on treatment outcomes of children with severe GH deficiency. The pharmacogenomics journal. 2011. Costalonga E F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature genetics. 2010. Dupuis Josée, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Leveraging learning from a phase III colorectal cancer clinical trial: outcomes, methodology, meta-analysis and pharmacogenetics. Transactions of the American Clinical and Climatological Association. 2010. Goldberg Richard M, et al. PubMed

LinkOuts

HuGE:
IGF1
Comparative Toxicogenomics Database:
3479
ModBase:
P01343
P05019
HumanCyc Gene:
HS00381
HGNC:
5464

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