Gene:
HMOX1
heme oxygenase (decycling) 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  HO-1; bK286B10
PharmGKB Accession Id: PA29341

Details

Cytogenetic Location: chr22 : q13.1 - q12.3
GP mRNA Boundary: chr22 : 35777060 - 35790207
GP Gene Boundary: chr22 : 35767060 - 35793207
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. HIF-1-alpha transcription factor network - (Pathway Interaction Database NCI-Nature Curated)
  2. il-10 anti-inflammatory signaling pathway - (BioCarta via Pathway Interaction Database)
  3. oxidative stress induced gene expression via nrf2 - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
cisplatin

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Ototoxicity

Publications related to HMOX1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene therapy for cisplatin-induced ototoxicity: a systematic review of in vitro and experimental animal studies. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2012. Waissbluth Sofia, et al. PubMed

LinkOuts

NCBI Gene:
3162
OMIM:
141250
606963
UCSC Genome Browser:
NM_002133
RefSeq RNA:
NM_002133
RefSeq Protein:
NP_002124
RefSeq DNA:
NG_023030
NT_011520
UniProtKB:
HMOX1_HUMAN (P09601)
Q6FH11_HUMAN (Q6FH11)
Ensembl:
ENSG00000100292
GenAtlas:
HMOX1
GeneCard:
HMOX1
MutDB:
HMOX1
ALFRED:
LO075307W
HuGE:
HMOX1
Comparative Toxicogenomics Database:
3162
ModBase:
P09601
HumanCyc Gene:
HS02027
HGNC:
5013

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