Gene:
PTGFR
prostaglandin F receptor (FP)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for PTGFR

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs3753380 NC_000001.10:g.78956432T>C, NC_000001.11:g.78490747T>C, NM_000959.3:c.-562T>C, NM_001039585.1:c.-562T>C, XM_006710781.2:c.-72-1925T>C, XR_426624.2:n.-227T>C, XR_946715.1:n.-227T>C, rs17573497
T > C
SNP
No VIP available CA VA
rs3766355 NC_000001.10:g.78957441C>A, NC_000001.11:g.78491756C>A, NM_000959.3:c.-73+520C>A, NM_001039585.1:c.-73+520C>A, XM_006710781.2:c.-72-916C>A, XR_426624.2:n.263+520C>A, XR_946715.1:n.263+520C>A, rs58238011
C > A
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  FP
PharmGKB Accession Id: PA290

Details

Cytogenetic Location: chr1 : p31.1 - p31.1
GP mRNA Boundary: chr1 : 78956728 - 79006386
GP Gene Boundary: chr1 : 78946728 - 79009386
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Celecoxib Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of celecoxib and candidate genes interacting with celecoxib and involved in the regulation of cell cycle, apoptosis and angiogenesis by celecoxib.
  1. Ibuprofen Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of ibuprofen (IBU).

External Pathways

Links to non-PharmGKB pathways.

  1. eicosanoid metabolism - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
bimatoprost
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
latanoprost

Curated Information ?

Publications related to PTGFR: 7

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma. Current eye research. 2016. Zhang Pu, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients. European journal of clinical pharmacology. 2014. Gao Li-Chen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Molecular psychiatry. 2013. Chen D T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Blood gene expression correlated with tic severity in medicated and unmedicated patients with Tourette Syndrome. Pharmacogenomics. 2010. Liao Isaac H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity. Bioorganic & medicinal chemistry. 2009. Feng Zixia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Commercially available prostaglandin analogs for the reduction of intraocular pressure: similarities and differences. Survey of ophthalmology. 2008. Bean Gerald W, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between genetic polymorphisms of the prostaglandin F2alpha receptor gene and response to latanoprost. Ophthalmology. 2007. Sakurai Mayumi, et al. PubMed

LinkOuts

NCBI Gene:
5737
OMIM:
600563
UCSC Genome Browser:
NM_000959
RefSeq RNA:
NM_000959
NM_001039585
RefSeq Protein:
NP_000950
NP_001034674
RefSeq DNA:
NT_032977
UniProtKB:
PF2R_HUMAN (P43088)
Q6RYQ6_HUMAN (Q6RYQ6)
Ensembl:
ENSG00000122420
GenAtlas:
PTGFR
GeneCard:
PTGFR
MutDB:
PTGFR
ALFRED:
LO080295Y
HuGE:
PTGFR
Comparative Toxicogenomics Database:
5737
ModBase:
P43088
HumanCyc Gene:
HS04569
IUPHAR Receptor:
FP (344)
HGNC:
9600

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