Gene:
GRM3
glutamate receptor, metabotropic 3

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for GRM3

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs13242038 NC_000007.13:g.86314420C>T, NC_000007.14:g.86685104C>T, NM_000840.2:c.-141+40232C>T, XM_005250287.1:c.84+40232C>T, XM_005250289.1:c.100+40232C>T, XM_011516088.1:c.-141+40232C>T, XM_011516089.1:c.-141+40232C>T, XM_011516090.1:c.-141+40232C>T
C > T
SNP
No VIP available CA VA
rs1468412 NC_000007.13:g.86433451A>T, NC_000007.14:g.86804135A>T, NM_000840.2:c.1324+17019A>T, XM_005250286.1:c.1324+17019A>T, XM_005250287.1:c.940+17019A>T, XM_005250288.1:c.1324+17019A>T, XM_005250289.1:c.101-34704A>T, XM_005250290.1:c.1324+17019A>T, XM_011516088.1:c.1324+17019A>T, XM_011516089.1:c.1325-10952A>T, XM_011516090.1:c.1324+17019A>T, rs10331026, rs10480415, rs17161010
A > T
SNP
No VIP available No Clinical Annotations available VA
rs1989796 NC_000007.13:g.86474313T>C, NC_000007.14:g.86844997T>C, NM_000840.2:c.2391+5092T>C, XM_005250286.1:c.2391+5092T>C, XM_005250287.1:c.2007+5092T>C, XM_005250288.1:c.1325-5373T>C, XM_005250289.1:c.1167+5092T>C, XM_011516088.1:c.1325-5373T>C, rs10375213, rs2299229, rs59168320
T > C
SNP
No VIP available CA VA
rs1990040 NC_000007.13:g.86313074A>G, NC_000007.14:g.86683758A>G, NM_000840.2:c.-141+38886A>G, XM_005250287.1:c.84+38886A>G, XM_005250289.1:c.100+38886A>G, XM_011516088.1:c.-141+38886A>G, XM_011516089.1:c.-141+38886A>G, XM_011516090.1:c.-141+38886A>G, rs17675465
A > G
SNP
No VIP available CA VA
rs2189814 NC_000007.13:g.86331756T>C, NC_000007.14:g.86702440T>C, NM_000840.2:c.-141+57568T>C, XM_005250287.1:c.84+57568T>C, XM_005250289.1:c.100+57568T>C, XM_011516088.1:c.-141+57568T>C, XM_011516089.1:c.-141+57568T>C, XM_011516090.1:c.-141+57568T>C, rs17675632
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2237558 NC_000007.13:g.86393536G>A, NC_000007.14:g.86764220G>A, NM_000840.2:c.-140-786G>A, XM_005250286.1:c.-926G>A, XM_005250287.1:c.85-22041G>A, XM_005250288.1:c.-926G>A, XM_005250289.1:c.101-74619G>A, XM_005250290.1:c.-926G>A, XM_011516088.1:c.-140-786G>A, XM_011516089.1:c.-140-786G>A, XM_011516090.1:c.-140-786G>A, rs60644010, rs61406302
G > A
SNP
No VIP available No Clinical Annotations available VA
rs2237562 NC_000007.13:g.86422232T>C, NC_000007.14:g.86792916T>C, NM_000840.2:c.1324+5800T>C, XM_005250286.1:c.1324+5800T>C, XM_005250287.1:c.940+5800T>C, XM_005250288.1:c.1324+5800T>C, XM_005250289.1:c.101-45923T>C, XM_005250290.1:c.1324+5800T>C, XM_011516088.1:c.1324+5800T>C, XM_011516089.1:c.1324+5800T>C, XM_011516090.1:c.1324+5800T>C, XR_927721.1:n.1425+271A>G, rs57635632
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2282966 NC_000007.13:g.86475667G>A, NC_000007.14:g.86846351G>A, NM_000840.2:c.2392-4019G>A, XM_005250286.1:c.2392-4019G>A, XM_005250287.1:c.2008-4019G>A, XM_005250288.1:c.1325-4019G>A, XM_005250289.1:c.1168-4019G>A, XM_011516088.1:c.1325-4019G>A, rs10365080, rs7804100
G > A
SNP
No VIP available No Clinical Annotations available VA
rs2299214 NC_000007.13:g.86309106C>T, NC_000007.14:g.86679790C>T, NM_000840.2:c.-141+34918C>T, XM_005250287.1:c.84+34918C>T, XM_005250289.1:c.100+34918C>T, XM_011516088.1:c.-141+34918C>T, XM_011516089.1:c.-141+34918C>T, XM_011516090.1:c.-141+34918C>T, rs60400850, rs9791754
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2299225 NC_000007.13:g.86447580T>G, NC_000007.14:g.86818264T>G, NM_000840.2:c.1325-20575T>G, XM_005250286.1:c.1325-20575T>G, XM_005250287.1:c.941-20575T>G, XM_005250288.1:c.1324+31148T>G, XM_005250289.1:c.101-20575T>G, XM_005250290.1:c.1325-14758T>G, XM_011516088.1:c.1324+31148T>G, XM_011516090.1:c.1325-14758T>G, rs17765182, rs56919395
T > G
SNP
No VIP available CA VA
rs274618 NC_000007.13:g.86272016T>A, NC_000007.14:g.86642700T>A, NM_000840.2:c.-2313T>A, XM_005250287.1:c.-2089T>A, XM_005250289.1:c.-2073T>A, rs10330593, rs56649261
T > A
SNP
No VIP available CA VA
rs274622 NC_000007.13:g.86272940C>T, NC_000007.14:g.86643624C>T, NM_000840.2:c.-1389C>T, XM_005250287.1:c.-1165C>T, XM_005250289.1:c.-1149C>T, XM_011516088.1:c.-1389C>T, XM_011516089.1:c.-1389C>T, XM_011516090.1:c.-1389C>T, rs10358739
C > T
SNP
No VIP available CA VA
rs6465084 NC_000007.13:g.86403475A>G, NC_000007.14:g.86774159A>G, NM_000840.2:c.468+8546A>G, XM_005250286.1:c.468+8546A>G, XM_005250287.1:c.85-12102A>G, XM_005250288.1:c.468+8546A>G, XM_005250289.1:c.101-64680A>G, XM_005250290.1:c.468+8546A>G, XM_011516088.1:c.468+8546A>G, XM_011516089.1:c.468+8546A>G, XM_011516090.1:c.468+8546A>G, XR_927721.1:n.2616T>C, rs10385355
A > G
SNP
No VIP available No Clinical Annotations available VA
rs6465088 NC_000007.13:g.86470554T>G, NC_000007.14:g.86841238T>G, NM_000840.2:c.2391+1333T>G, XM_005250286.1:c.2391+1333T>G, XM_005250287.1:c.2007+1333T>G, XM_005250288.1:c.1325-9132T>G, XM_005250289.1:c.1167+1333T>G, XM_011516088.1:c.1325-9132T>G, rs10487053, rs17161029, rs57316790
T > G
SNP
No VIP available No Clinical Annotations available VA
rs6947784 NC_000007.13:g.86395556G>C, NC_000007.14:g.86766240G>C, NM_000840.2:c.468+627G>C, XM_005250286.1:c.468+627G>C, XM_005250287.1:c.85-20021G>C, XM_005250288.1:c.468+627G>C, XM_005250289.1:c.101-72599G>C, XM_005250290.1:c.468+627G>C, XM_011516088.1:c.468+627G>C, XM_011516089.1:c.468+627G>C, XM_011516090.1:c.468+627G>C, rs59159779
G > C
SNP
No VIP available CA VA
rs724226 NC_000007.13:g.86325374A>G, NC_000007.14:g.86696058A>G, NM_000840.2:c.-141+51186A>G, XM_005250287.1:c.84+51186A>G, XM_005250289.1:c.100+51186A>G, XM_011516088.1:c.-141+51186A>G, XM_011516089.1:c.-141+51186A>G, XM_011516090.1:c.-141+51186A>G, rs59914090, rs802476
A > G
SNP
No VIP available No Clinical Annotations available VA
rs7789655 NC_000007.13:g.86481013T>G, NC_000007.14:g.86851697T>G, NM_000840.2:c.2566+1153T>G, XM_005250286.1:c.2566+1153T>G, XM_005250287.1:c.2182+1153T>G, XM_005250288.1:c.1499+1153T>G, XM_005250289.1:c.1342+1153T>G, XM_011516088.1:c.1499+1153T>G, rs10381422, rs12704292, rs59016638
T > G
SNP
No VIP available No Clinical Annotations available VA
rs917071 NC_000007.13:g.86353781C>T, NC_000007.14:g.86724465C>T, NM_000840.2:c.-140-40541C>T, XM_005250287.1:c.85-61796C>T, XM_005250289.1:c.100+79593C>T, XM_011516088.1:c.-140-40541C>T, XM_011516089.1:c.-140-40541C>T, XM_011516090.1:c.-140-40541C>T, rs10341047, rs58097802
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  GPRC1C; MGLUR3; mGlu3
PharmGKB Accession Id: PA28992

Details

Cytogenetic Location: chr7 : q21.11 - q21.2
GP mRNA Boundary: chr7 : 86273230 - 86494193
GP Gene Boundary: chr7 : 86263230 - 86497193
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GRM3: 10

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia. Psychopharmacology. 2015. Bishop Jeffrey R, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2014. Kaur Harpreet, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms. British journal of clinical pharmacology. 2014. Reynolds Gavin P, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Metabotropic glutamate receptor 3 is associated with heroin dependence but not depression or schizophrenia in a Chinese population. PloS one. 2014. Jia Wei, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia. The American journal of psychiatry. 2011. Greenwood Tiffany A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. The pharmacogenomics journal. 2011. Gupta A, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia. The pharmacogenomics journal. 2009. Fijal B A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatric genetics. 2007. Bishop Jeffrey R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. Schizophrenia research. 2005. Bishop Jeffrey R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatric genetics. 2003. Fujii Yo, et al. PubMed

LinkOuts

NCBI Gene:
2913
OMIM:
601115
UCSC Genome Browser:
NM_000840
RefSeq RNA:
NM_000840
RefSeq Protein:
NP_000831
RefSeq DNA:
NT_007933
NT_079595
UniProtKB:
A4D1D0_HUMAN (A4D1D0)
GRM3_HUMAN (Q14832)
Ensembl:
ENSG00000198822
GenAtlas:
GRM3
GeneCard:
GRM3
MutDB:
GRM3
ALFRED:
LO003288V
HuGE:
GRM3
Comparative Toxicogenomics Database:
2913
ModBase:
Q14832
IUPHAR Receptor:
mGlu3 (291)
HGNC:
4595

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