Gene:
GRM1
glutamate receptor, metabotropic 1

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

Overview

Alternate Names:  protein phosphatase 1, regulatory subunit 85
Alternate Symbols:  GPRC1A; MGLUR1; PPP1R85; mGlu1
PharmGKB Accession Id: PA28990

Details

Cytogenetic Location: chr6 : q24.3 - q24.3
GP mRNA Boundary: chr6 : 146286032 - 146758782
GP Gene Boundary: chr6 : 146276032 - 146761782
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
galantamine
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
memantine

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Alcoholism
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Schizophrenia

Publications related to GRM1: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Kynurenine pathway and cognitive impairments in schizophrenia: Pharmacogenetics of galantamine and memantine. Schizophrenia research. Cognition. 2016. Koola Maju Mathew. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia. The American journal of psychiatry. 2011. Greenwood Tiffany A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pathway based analysis of genotypes in relation to alcohol dependence. The pharmacogenomics journal. 2011. Reimers M A, et al. PubMed

LinkOuts

NCBI Gene:
2911
OMIM:
604473
UCSC Genome Browser:
NM_000838
RefSeq RNA:
NM_000838
NM_001114329
RefSeq Protein:
NP_000829
NP_001107801
RefSeq DNA:
NG_012839
NT_025741
UniProtKB:
GRM1_HUMAN (Q13255)
Q59HC2_HUMAN (Q59HC2)
Ensembl:
ENSG00000152822
GenAtlas:
GRM1
GeneCard:
GRM1
MutDB:
GRM1
ALFRED:
LO003056O
HuGE:
GRM1
Comparative Toxicogenomics Database:
2911
ModBase:
Q9UGT0
HumanCyc Gene:
HS07857
IUPHAR Receptor:
mGlu1 (289)
HGNC:
4593

Common Searches