Gene:
GRIA2
glutamate receptor, ionotropic, AMPA 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  GLUR2
Alternate Symbols:  GLURB; GluA2
PharmGKB Accession Id: PA28967

Details

Cytogenetic Location: chr4 : q32.1 - q32.1
GP mRNA Boundary: chr4 : 158141736 - 158287227
GP Gene Boundary: chr4 : 158131736 - 158290227
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GRIA2: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis. Pharmacogenomics. 2015. Higgins Gerald A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction. Psychiatry research. 2012. Bishop Jeffrey R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. American journal of human genetics. 2008. Mill Jonathan, et al. PubMed

LinkOuts

NCBI Gene:
2891
OMIM:
138247
UCSC Genome Browser:
NM_000826
RefSeq RNA:
NM_000826
NM_001083619
NM_001083620
RefSeq Protein:
NP_000817
NP_001077088
NP_001077089
RefSeq DNA:
NT_016354
UniProtKB:
GRIA2_HUMAN (P42262)
Ensembl:
ENSG00000120251
GenAtlas:
GRIA2
GeneCard:
GRIA2
MutDB:
GRIA2
ALFRED:
LO146609A
HuGE:
GRIA2
Comparative Toxicogenomics Database:
2891
ModBase:
P42262
HumanCyc Gene:
HS04382
HGNC:
4572

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