Gene:
GRIA1
glutamate receptor, ionotropic, AMPA 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for GRIA1

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs1994862 NC_000005.10:g.153609350C>G, NC_000005.9:g.152988910C>G, NM_000827.3:c.221-37578C>G, NM_001114183.1:c.221-37578C>G, NM_001258019.1:c.221-40980C>G, NM_001258020.1:c.-65-37578C>G, NM_001258021.1:c.251-37578C>G, NM_001258022.1:c.251-37578C>G, NM_001258023.1:c.14-37578C>G, NR_047578.1:n.448-37578C>G, XM_011537635.1:c.161-37578C>G, XR_427776.2:n.491-37578C>G, rs17592384
C > G
C > T
SNP
No VIP available CA VA
rs4958381 NC_000005.10:g.154651307T>C, NC_000005.9:g.154030867T>C
T > C
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  GLUR1
Alternate Symbols:  GLURA; GluA1
PharmGKB Accession Id: PA28966

Details

Cytogenetic Location: chr5 : q31.1 - q33.2
GP mRNA Boundary: chr5 : 152870084 - 153193429
GP Gene Boundary: chr5 : 152860084 - 153196429
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GRIA1: 7

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Possible biomarkers modulating haloperidol efficacy and/or tolerability. Pharmacogenomics. 2016. Porcelli Stefano, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Inherited genetic variation in childhood acute lymphoblastic leukemia. Blood. 2015. Moriyama Takaya, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of childhood acute lymphoblastic leukemia. Pharmacogenomics. 2014. Lopez-Lopez Elixabet, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2013. Relling Mary V, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction. Psychiatry research. 2012. Bishop Jeffrey R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressant drugs: current clinical practice and future directions. Pharmacogenomics. 2012. Narasimhan Sneha, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity. Clinical pharmacology and therapeutics. 2010. Chen S-H, et al. PubMed

LinkOuts

NCBI Gene:
2890
OMIM:
138248
UCSC Genome Browser:
NM_000827
RefSeq RNA:
NM_000827
NM_001114183
RefSeq Protein:
NP_000818
NP_001107655
RefSeq DNA:
NT_029289
UniProtKB:
GRIA1_HUMAN (P42261)
Q59GL5_HUMAN (Q59GL5)
Ensembl:
ENSG00000155511
GenAtlas:
GRIA1
GeneCard:
GRIA1
MutDB:
GRIA1
ALFRED:
LO004256R
HuGE:
GRIA1
Comparative Toxicogenomics Database:
2890
ModBase:
P42261
HumanCyc Gene:
HS08057
HGNC:
4571

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