Gene:
PTGDR2
prostaglandin D2 receptor 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  GPR44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells
Alternate Symbols:  CD294; CRTH2; DP2
PharmGKB Accession Id: PA28891

Details

Cytogenetic Location: chr11 : q12.2 - q12.2
GP mRNA Boundary: chr11 : 60618398 - 60623444
GP Gene Boundary: chr11 : 60615398 - 60633444
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Ibuprofen Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of ibuprofen (IBU).

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
loratadine

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Urticaria

Publications related to PTGDR2: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of CRTH2 gene polymorphisms with the required dose of antihistamines in patients with chronic urticaria. Pharmacogenomics. 2009. Palikhe Nami Shrestha, et al. PubMed

LinkOuts

NCBI Gene:
11251
OMIM:
604837
UCSC Genome Browser:
NM_004778
RefSeq RNA:
NM_004778
RefSeq Protein:
NP_004769
RefSeq DNA:
NG_016170
NT_167190
UniProtKB:
GPR44_HUMAN (Q9Y5Y4)
Ensembl:
ENSG00000183134
GenAtlas:
GPR44
GeneCard:
GPR44
MutDB:
GPR44
ALFRED:
LO242835Y
HuGE:
GPR44
Comparative Toxicogenomics Database:
11251
ModBase:
Q9Y5Y4
IUPHAR Receptor:
DP2 (339)
HGNC:
4502

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