Gene:
GLP1R
glucagon-like peptide 1 receptor

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for GLP1R

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs10305420 NC_000006.11:g.39016636C>T, NC_000006.12:g.39048860C>T, NM_002062.3:c.20C>T, NP_002053.3:p.Pro7Leu, XR_241888.1:n.80C>T, XR_241889.1:n.80C>T, XR_926153.1:n.80C>T, XR_926154.1:n.80C>T, XR_926155.1:n.80C>T
C > T
SNP
P7L
No VIP available CA VA
rs2268639 NC_000006.11:g.39050622T>A, NC_000006.12:g.39082846T>A, NM_002062.3:c.1224+2107T>A, XR_241888.1:n.1284+2107T>A, XR_241889.1:n.1284+2107T>A, XR_926153.1:n.1284+2107T>A, XR_926154.1:n.1284+2107T>A, XR_926155.1:n.1284+2107T>A, rs59254920
T > A
SNP
No VIP available CA VA
rs6923761 NC_000006.11:g.39034072G>A, NC_000006.12:g.39066296G>A, NM_002062.3:c.502G>A, NP_002053.3:p.Gly168Ser, XR_241888.1:n.562G>A, XR_241889.1:n.562G>A, XR_926153.1:n.562G>A, XR_926154.1:n.562G>A, XR_926155.1:n.562G>A, rs17339269, rs52795843, rs60911077
G > A
SNP
G168S
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA28725

Details

Cytogenetic Location: chr6 : p21.2 - p21.2
GP mRNA Boundary: chr6 : 39016557 - 39056657
GP Gene Boundary: chr6 : 39006557 - 39059657
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GLP1R: 7

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A missense variant in GLP1R gene is associated with the glycemic response to treatment with gliptins. Diabetes, obesity & metabolism. 2016. Javorský Martin, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic variability in GLP-1 receptor is associated with inter-individual differences in weight lowering potential of liraglutide in obese women with PCOS: a pilot study. European journal of clinical pharmacology. 2015. Jensterle Mojca, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain. Pharmacogenomics. 2014. Brandl Eva J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration. International journal of pharmaceutics. 2008. Gedulin Bronislava R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Exenatide: a GLP-1 receptor agonist as novel therapy for Type 2 diabetes mellitus. Expert opinion on pharmacotherapy. 2006. Briones Mariele, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness. Regulatory peptides. 2005. Beinborn Martin, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. The Journal of biological chemistry. 1993. Göke R, et al. PubMed

LinkOuts

NCBI Gene:
2740
OMIM:
138032
UCSC Genome Browser:
NM_002062
RefSeq RNA:
NM_002062
RefSeq Protein:
NP_002053
RefSeq DNA:
NT_007592
UniProtKB:
GLP1R_HUMAN (P43220)
Ensembl:
ENSG00000112164
GenAtlas:
GLP1R
GeneCard:
GLP1R
MutDB:
GLP1R
ALFRED:
LO011540L
HuGE:
GLP1R
ModBase:
P43220
HumanCyc Gene:
HS03526
IUPHAR Receptor:
GLP-1 (249)
HGNC:
4324

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