Gene:
GLI3
GLI family zinc finger 3

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  DNA-binding protein; GCPS; PHS; oncogene GLI3; zinc finger protein GLI3
Alternate Symbols:  ACLS; PAP-A; PAPA; PAPA1; PAPB; PPDIV
PharmGKB Accession Id: PA28722

Details

Cytogenetic Location: chr7 : p13 - p14.1
GP mRNA Boundary: chr7 : 42000547 - 42277469
GP Gene Boundary: chr7 : 41997547 - 42287469
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Hedgehog signaling events mediated by Gli proteins - (Pathway Interaction Database NCI-Nature Curated)
No related genes are available

Curated Information ?

Publications related to GLI3: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus. American journal of human genetics. 2008. Craig David W, et al. PubMed

LinkOuts

NCBI Gene:
2737
OMIM:
146510
165240
174200
174700
175700
200990
241800
UCSC Genome Browser:
NM_000168
RefSeq RNA:
NM_000168
RefSeq Protein:
NP_000159
RefSeq DNA:
NG_008434
NT_007819
NT_079592
UniProtKB:
GLI3_HUMAN (P10071)
Ensembl:
ENSG00000106571
GenAtlas:
GLI3
GeneCard:
GLI3
MutDB:
GLI3
ALFRED:
LO007847A
HuGE:
GLI3
Comparative Toxicogenomics Database:
2737
ModBase:
P10071
HumanCyc Gene:
HS02924
HGNC:
4319

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