Gene:
GGT1
gamma-glutamyltransferase 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

Overview

Alternate Names:  GGT
Alternate Symbols:  CD224; D22S672; D22S732
PharmGKB Accession Id: PA28662

Details

Cytogenetic Location: chr22 : q11.23 - q11.23
GP mRNA Boundary: chr22 : 24979629 - 25024972
GP Gene Boundary: chr22 : 24969629 - 25027972
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

LinkOuts

NCBI Gene:
2678
OMIM:
231950
612346
UCSC Genome Browser:
NM_005265
RefSeq RNA:
NM_001032364
NM_001032365
NM_005265
NM_013430
RefSeq Protein:
NP_001027536
NP_001027537
NP_005256
NP_038347
RefSeq DNA:
NG_008111
NT_011520
UniProtKB:
GGT1_HUMAN (P19440)
Ensembl:
ENSG00000100031
GenAtlas:
GGT1
GeneCard:
GGT1
MutDB:
GGT1
ALFRED:
LO254433V
HuGE:
GGT1
Comparative Toxicogenomics Database:
2678
ModBase:
P19440
HumanCyc Gene:
HS01957
HGNC:
4250

Common Searches