Gene:
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  GABA(A) receptor, beta 3
Alternate Symbols:  None
PharmGKB Accession Id: PA28497

Details

Cytogenetic Location: chr15 : q12 - q12
GP mRNA Boundary: chr15 : 26788693 - 27018935
GP Gene Boundary: chr15 : 26785693 - 27028935
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GABRB3: 6

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pathway based analysis of genotypes in relation to alcohol dependence. The pharmacogenomics journal. 2011. Reimers M A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Blood gene expression correlated with tic severity in medicated and unmedicated patients with Tourette Syndrome. Pharmacogenomics. 2010. Liao Isaac H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy. American journal of human genetics. 2008. Tanaka Miyabi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association between a GABRB3 polymorphism and autism. Molecular psychiatry. 2002. Buxbaum J D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium. American journal of medical genetics. 1999. Maestrini E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers. American journal of human genetics. 1998. Cook E H, et al. PubMed

LinkOuts

NCBI Gene:
2562
OMIM:
137192
612269
UCSC Genome Browser:
NM_000814
RefSeq RNA:
NM_000814
NM_001191320
NM_001191321
NM_021912
RefSeq Protein:
NP_000805
NP_001178249
NP_001178250
NP_068712
RefSeq DNA:
NG_012836
NT_026446
UniProtKB:
GBRB3_HUMAN (P28472)
Ensembl:
ENSG00000166206
GenAtlas:
GABRB3
GeneCard:
GABRB3
MutDB:
GABRB3
ALFRED:
LO000748T
HuGE:
GABRB3
Comparative Toxicogenomics Database:
2562
ModBase:
P28472
HumanCyc Gene:
HS09355
IUPHAR Receptor:
β3 (412)
HGNC:
4083

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