Gene:
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  GABA(A) receptor, alpha 4
Alternate Symbols:  None
PharmGKB Accession Id: PA28492

Details

Cytogenetic Location: chr4 : p12 - p12
GP mRNA Boundary: chr4 : 46920917 - 46996424
GP Gene Boundary: chr4 : 46917917 - 47006424
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. cardiac protection against ros - (BioCarta via Pathway Interaction Database)
  2. gamma-aminobutyric acid receptor life cycle pathway - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GABRA4: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pathway based analysis of genotypes in relation to alcohol dependence. The pharmacogenomics journal. 2011. Reimers M A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker. Pharmacogenomics. 2011. Morag Ayelet, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Expectations, validity, and reality in pharmacogenetics. Journal of clinical epidemiology. 2010. Limdi Nita A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. Pharmacogenetics and genomics. 2008. Inada Toshiya, et al. PubMed

LinkOuts

NCBI Gene:
2557
OMIM:
137141
UCSC Genome Browser:
NM_000809
RefSeq RNA:
NM_000809
NM_001204266
NM_001204267
RefSeq Protein:
NP_000800
NP_001191195
NP_001191196
RefSeq DNA:
NG_011809
NT_006238
UniProtKB:
GBRA4_HUMAN (P48169)
Ensembl:
ENSG00000109158
GenAtlas:
GABRA4
GeneCard:
GABRA4
MutDB:
GABRA4
ALFRED:
LO004297W
HuGE:
GABRA4
Comparative Toxicogenomics Database:
2557
ModBase:
P48169
HumanCyc Gene:
HS03206
IUPHAR Receptor:
α4 (407)
HGNC:
4078

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