Gene:
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  GABA(A) receptor, alpha 2
Alternate Symbols:  None
PharmGKB Accession Id: PA28490

Details

Cytogenetic Location: chr4 : p12 - p12
GP mRNA Boundary: chr4 : 46246470 - 46392056
GP Gene Boundary: chr4 : 46243470 - 46402056
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
antidepressants
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
antipsychotics
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
opioids

Curated Information ?

Publications related to GABRA2: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Breaking Barriers in the Genomics and Pharmacogenetics of Drug Addiction. Clinical pharmacology and therapeutics. 2010. Ho M K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2006. Enoch Mary-Anne, et al. PubMed

LinkOuts

NCBI Gene:
2555
OMIM:
103780
137140
UCSC Genome Browser:
NM_000807
RefSeq RNA:
NM_000807
NM_001114175
RefSeq Protein:
NP_000798
NP_001107647
RefSeq DNA:
NG_012835
NT_006238
UniProtKB:
A8K0U7_HUMAN (A8K0U7)
GBRA2_HUMAN (P47869)
Ensembl:
ENSG00000151834
GenAtlas:
GABRA2
GeneCard:
GABRA2
MutDB:
GABRA2
ALFRED:
LO000628Q
HuGE:
GABRA2
Comparative Toxicogenomics Database:
2555
ModBase:
P47869
HumanCyc Gene:
HS07773
IUPHAR Receptor:
α2 (405)
HGNC:
4076

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