Gene:
ACKR1
atypical chemokine receptor 1 (Duffy blood group)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  DARC; FY; atypical chemokine receptor 1
Alternate Symbols:  CCBP1; CD234; Dfy; GPD
PharmGKB Accession Id: PA28451

Details

Cytogenetic Location: chr1 : q23.2 - q22
GP mRNA Boundary: chr1 : 159173803 - 159176290
GP Gene Boundary: chr1 : 159163803 - 159179290
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Publications related to ACKR1: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. Cell host & microbe. 2008. He Weijing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Complex signatures of natural selection at the Duffy blood group locus. American journal of human genetics. 2002. Hamblin Martha T, et al. PubMed

LinkOuts

NCBI Gene:
2532
OMIM:
110700
611162
611862
UCSC Genome Browser:
NM_002036
RefSeq RNA:
NM_001122951
NM_002036
RefSeq Protein:
NP_001116423
NP_002027
RefSeq DNA:
NG_011626
NT_004487
HuGE:
DARC
Comparative Toxicogenomics Database:
2532
ModBase:
Q9UQE1
IUPHAR Receptor:
FY (316)
HGNC:
4035

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