Gene:
FGF1
fibroblast growth factor 1 (acidic)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  FGFA; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; heparin-binding growth factor 1
Alternate Symbols:  AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-alpha; GLIO703; HBGF1
PharmGKB Accession Id: PA28105

Details

Cytogenetic Location: chr5 : q31.3 - q31.3
GP mRNA Boundary: chr5 : 141971743 - 142077635
GP Gene Boundary: chr5 : 141968743 - 142087635
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

Curated Information ?

Curated Information ?

Curated Information ?

Publications related to FGF1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Systematic review of pharmacoeconomic studies of pharmacogenomic tests. Pharmacogenomics. 2010. Beaulieu Mathieu, et al. PubMed

LinkOuts

UniProtKB:
FGF1_HUMAN (P05230)
Q16089_HUMAN (Q16089)
Ensembl:
ENSG00000113578
GenAtlas:
FGF1
GeneCard:
FGF1
MutDB:
FGF1
ALFRED:
LO014592V
HuGE:
FGF1
Comparative Toxicogenomics Database:
2246
ModBase:
P05230
HumanCyc Gene:
HS03697
HGNC:
3665

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