Gene:
ESRRA
estrogen-related receptor alpha

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  ESRL1
Alternate Symbols:  ERR1; ERRa; ERRalpha; NR3B1
PharmGKB Accession Id: PA27887

Details

Cytogenetic Location: chr11 : q13.1 - q13.1
GP mRNA Boundary: chr11 : 64072990 - 64084215
GP Gene Boundary: chr11 : 64062990 - 64087215
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. regulation of pgc-1a - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
gemfibrozil
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
tamoxifen

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Breast Neoplasms
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Obesity

Publications related to ESRRA: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ERRalpha is a marker of tamoxifen response and survival in triple-negative breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015. Manna Subrata, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil. Genetics in medicine : official journal of the American College of Medical Genetics. 2002. Bossé Yohan, et al. PubMed

LinkOuts

NCBI Gene:
2101
OMIM:
601998
UCSC Genome Browser:
NM_004451
RefSeq RNA:
NM_004451
RefSeq Protein:
NP_004442
RefSeq DNA:
NT_167190
UniProtKB:
ERR1_HUMAN (P11474)
Q569H8_HUMAN (Q569H8)
Ensembl:
ENSG00000173153
GenAtlas:
ESRRA
GeneCard:
ESRRA
MutDB:
ESRRA
HuGE:
ESRRA
Comparative Toxicogenomics Database:
2101
ModBase:
P11474
HumanCyc Gene:
HS10622
HGNC:
3471

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