Gene:
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  DYRK; DYRK1; MNBH
Alternate Symbols:  None
PharmGKB Accession Id: PA27545

Details

Cytogenetic Location: chr21 : q22.13 - q22.13
GP mRNA Boundary: chr21 : 38739859 - 38887679
GP Gene Boundary: chr21 : 38729859 - 38890679
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Publications related to DYRK1A: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. American journal of human genetics. 2008. Canzonetta Claudia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly. American journal of human genetics. 2008. Møller Rikke S, et al. PubMed

LinkOuts

NCBI Gene:
1859
OMIM:
600855
UCSC Genome Browser:
NM_001396
RefSeq RNA:
NM_001396
NM_101395
NM_130436
NM_130437
NM_130438
RefSeq Protein:
NP_001387
NP_567824
NP_569120
NP_569121
NP_569122
RefSeq DNA:
NG_009366
NT_011512
UniProtKB:
DYR1A_HUMAN (Q13627)
Ensembl:
ENSG00000157540
GenAtlas:
DYRK1A
GeneCard:
DYRK1A
MutDB:
DYRK1A
ALFRED:
LO037869H
HuGE:
DYRK1A
Comparative Toxicogenomics Database:
1859
ModBase:
Q13627
HumanCyc Gene:
HS08219
HGNC:
3091

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