Gene:
CXCR4
chemokine (C-X-C motif) receptor 4

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  CD184; D2S201E; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; fusin
PharmGKB Accession Id: PA27058

Details

Cytogenetic Location: chr2 : q22.1 - q22.1
GP mRNA Boundary: chr2 : 136871919 - 136875725
GP Gene Boundary: chr2 : 136868919 - 136885725
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to CXCR4: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The Dual Role of Pharmacogenetics in HIV Treatment: Mutations and Polymorphisms Regulating Antiretroviral Drug Resistance and Disposition. Pharmacological reviews. 2012. Michaud Veronique, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HIV-1 antiretroviral drug therapy. Cold Spring Harbor perspectives in medicine. 2012. Arts Eric J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Systematic review of pharmacoeconomic studies of pharmacogenomic tests. Pharmacogenomics. 2010. Beaulieu Mathieu, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Chemokine and chemokine receptor expression after combined anti-HIV-1 interleukin-2 therapy. AIDS (London, England). 1999. Blanco J, et al. PubMed

LinkOuts

NCBI Gene:
7852
OMIM:
162643
193670
UCSC Genome Browser:
NM_003467
RefSeq RNA:
NM_001008540
NM_003467
RefSeq Protein:
NP_001008540
NP_003458
RefSeq DNA:
NG_011587
NT_022135
UniProtKB:
CXCR4_HUMAN (P61073)
Ensembl:
ENSG00000121966
GenAtlas:
CXCR4
GeneCard:
CXCR4
MutDB:
CXCR4
ALFRED:
LO099212X
HuGE:
CXCR4
Comparative Toxicogenomics Database:
7852
ModBase:
P61073
HumanCyc Gene:
HS04535
IUPHAR Receptor:
CXCR4 (71)
HGNC:
2561

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