Gene:
CHKA
choline kinase alpha

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  CHK
Alternate Symbols:  CKI
PharmGKB Accession Id: PA26468

Details

Cytogenetic Location: chr11 : q13.2 - q13.2
GP mRNA Boundary: chr11 : 67820326 - 67888858
GP Gene Boundary: chr11 : 67817326 - 67898858
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Diabetes Mellitus, Type 2

Publications related to CHKA: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in african americans. PloS one. 2014. Jeff Janina M, et al. PubMed

LinkOuts

NCBI Gene:
1119
OMIM:
118491
UCSC Genome Browser:
NM_001277
RefSeq RNA:
NM_001277
NM_212469
RefSeq Protein:
NP_001268
NP_997634
RefSeq DNA:
NT_167190
UniProtKB:
CHKA_HUMAN (P35790)
Ensembl:
ENSG00000110721
GenAtlas:
CHKA
GeneCard:
CHKA
MutDB:
CHKA
ALFRED:
LO041416Q
HuGE:
CHKA
Comparative Toxicogenomics Database:
1119
ModBase:
P35790
HumanCyc Gene:
HS03334
HGNC:
1937

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