Gene:
CD80
CD80 molecule

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  B-lymphocyte activation antigen B7; CD28LG; CD28LG1
Alternate Symbols:  B7-1; B7.1
PharmGKB Accession Id: PA26239

Details

Cytogenetic Location: chr3 : q13.33 - q13.33
GP mRNA Boundary: chr3 : 119243140 - 119278481
GP Gene Boundary: chr3 : 119240140 - 119288481
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. IL12 signaling mediated by STAT4 - (Pathway Interaction Database NCI-Nature Curated)
  2. TCR signaling in naïve CD4+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  3. TCR signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  4. the co-stimulatory signal during t-cell activation - (BioCarta via Pathway Interaction Database)

LinkOuts

NCBI Gene:
941
OMIM:
112203
UCSC Genome Browser:
NM_005191
RefSeq RNA:
NM_005191
RefSeq Protein:
NP_005182
RefSeq DNA:
NT_005612
UniProtKB:
A0N0P2_HUMAN (A0N0P2)
CD80_HUMAN (P33681)
Ensembl:
ENSG00000121594
GenAtlas:
CD80
GeneCard:
CD80
MutDB:
CD80
ALFRED:
LO075411S
HuGE:
CD80
Comparative Toxicogenomics Database:
941
ModBase:
P33681
HumanCyc Gene:
HS04506
HGNC:
1700

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