Gene:
CCR6
chemokine (C-C motif) receptor 6

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  STRL22
Alternate Symbols:  BN-1; CD196; CKR-L3; CMKBR6; DCR2; DRY-6; GPR-CY4; GPR29
PharmGKB Accession Id: PA26171

Details

Cytogenetic Location: chr6 : q27 - q27
GP mRNA Boundary: chr6 : 167525295 - 167554168
GP Gene Boundary: chr6 : 167515295 - 167557168
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Arthritis, Rheumatoid

Publications related to CCR6: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans. Arthritis and rheumatism. 2010. Hughes Laura B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature genetics. 2010. Stahl Eli A, et al. PubMed

LinkOuts

NCBI Gene:
1235
OMIM:
601835
UCSC Genome Browser:
NM_004367
RefSeq RNA:
NM_004367
NM_031409
RefSeq Protein:
NP_004358
NP_113597
RefSeq DNA:
NT_025741
UniProtKB:
CCR6_HUMAN (P51684)
Ensembl:
ENSG00000112486
GenAtlas:
CCR6
GeneCard:
CCR6
MutDB:
CCR6
ALFRED:
LO020292P
HuGE:
CCR6
Comparative Toxicogenomics Database:
1235
ModBase:
P51684
IUPHAR Receptor:
CCR6 (63)
HGNC:
1607

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