Gene:
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

Overview

Alternate Names:  TNRC8
Alternate Symbols:  CAGH39; FGS4; LIN2
PharmGKB Accession Id: PA26081

Details

Cytogenetic Location: chrX : p11.4 - p11.4
GP mRNA Boundary: chrX : 41374187 - 41782415
GP Gene Boundary: chrX : 41371187 - 41792415
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

NCBI Gene:
8573
OMIM:
300172
300422
300749
UCSC Genome Browser:
NM_003688
RefSeq RNA:
NM_001126054
NM_001126055
NM_003688
RefSeq Protein:
NP_001119526
NP_001119527
NP_003679
RefSeq DNA:
NG_016754
NT_079573
UniProtKB:
CSKP_HUMAN (O14936)
Ensembl:
ENSG00000147044
GenAtlas:
CASK
GeneCard:
CASK
MutDB:
CASK
ALFRED:
LO023900O
HuGE:
CASK
Comparative Toxicogenomics Database:
8573
ModBase:
Q5VT19
HumanCyc Gene:
HS07384
HGNC:
1497

Common Searches