Gene:
NPY1R
neuropeptide Y receptor Y1

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  NPYR
Alternate Symbols:  None
PharmGKB Accession Id: PA258

Details

Cytogenetic Location: chr4 : q31.3 - q32.2
GP mRNA Boundary: chr4 : 164245116 - 164265984
GP Gene Boundary: chr4 : 164242116 - 164275984
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Sympathetic Nerve Pathway (Neuroeffector Junction)
    Simplified diagram of a sympathetic neuroeffector junction displaying genes which may be involved.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
NPY
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PYY

Curated Information ?

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tourette Syndrome

Publications related to NPY1R: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Blood gene expression correlated with tic severity in medicated and unmedicated patients with Tourette Syndrome. Pharmacogenomics. 2010. Liao Isaac H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Presynaptic and postsynaptic effects of neuropeptide Y in the rat pineal gland. Journal of neurochemistry. 1994. Simonneaux V, et al. PubMed

LinkOuts

NCBI Gene:
4886
OMIM:
162641
UCSC Genome Browser:
NM_000909
RefSeq RNA:
NM_000909
RefSeq Protein:
NP_000900
RefSeq DNA:
NT_016354
UniProtKB:
NPY1R_HUMAN (P25929)
Ensembl:
ENSG00000164128
GenAtlas:
NPY1R
GeneCard:
NPY1R
MutDB:
NPY1R
ALFRED:
LO134385Y
HuGE:
NPY1R
Comparative Toxicogenomics Database:
4886
ModBase:
P25929
HumanCyc Gene:
HS09023
IUPHAR Receptor:
Y1 (305)
HGNC:
7956

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