Gene:
NPY
neuropeptide Y

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  prepro-neuropeptide Y
Alternate Symbols:  PYY4
PharmGKB Accession Id: PA255

Details

Cytogenetic Location: chr7 : p15.1 - p15.3
GP mRNA Boundary: chr7 : 24323807 - 24331484
GP Gene Boundary: chr7 : 24313807 - 24334484
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Sympathetic Nerve Pathway (Neuroeffector Junction)
    Simplified diagram of a sympathetic neuroeffector junction displaying genes which may be involved.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
NPY1R
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
NPY2R

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
antipsychotics
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
thiazolidinediones

Curated Information ?

Publications related to NPY: 9

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Comprehensive evaluation of the neuropeptide-Y gene variants in the risk of obesity: a case-control study and meta-analysis. Pharmacogenetics and genomics. 2015. Zain Shamsul Mohd, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetics of antipsychotic-induced weight gain: update and current perspectives. Pharmacogenomics. 2013. Kao Amy Cc, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels. Schizophrenia research. 2009. Diaz Francisco J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. Clinica chimica acta; international journal of clinical chemistry. 2009. RuaƱo Gualberto, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variation in human NPY expression affects stress response and emotion. Nature. 2008. Zhou Zhifeng, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. Schizophrenia research. 2008. de Leon Jose, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. Alcoholism, clinical and experimental research. 2003. Pandey Subhash C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Presynaptic and postsynaptic effects of neuropeptide Y in the rat pineal gland. Journal of neurochemistry. 1994. Simonneaux V, et al. PubMed

LinkOuts

NCBI Gene:
4852
OMIM:
162640
UCSC Genome Browser:
NM_000905
RefSeq RNA:
NM_000905
RefSeq Protein:
NP_000896
RefSeq DNA:
NG_016148
NT_007819
NT_079592
UniProtKB:
A4D158_HUMAN (A4D158)
NPY_HUMAN (P01303)
Ensembl:
ENSG00000122585
GenAtlas:
NPY
GeneCard:
NPY
MutDB:
NPY
ALFRED:
LO038065W
HuGE:
NPY
Comparative Toxicogenomics Database:
4852
ModBase:
P01303
HumanCyc Gene:
HS04580
HGNC:
7955

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