Gene:
BMPR1B
bone morphogenetic protein receptor, type IB

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  ALK6; CDw293
PharmGKB Accession Id: PA25387

Details

Cytogenetic Location: chr4 : q22.3 - q24
GP mRNA Boundary: chr4 : 95679128 - 96079601
GP Gene Boundary: chr4 : 95669128 - 96082601
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Brachydactyly type B

Publications related to BMPR1B: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 2010. Harvey Richard C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. American journal of human genetics. 2007. Lehmann K, et al. PubMed

LinkOuts

NCBI Gene:
658
OMIM:
112600
603248
609441
UCSC Genome Browser:
NM_001203
RefSeq RNA:
NM_001203
RefSeq Protein:
NP_001194
RefSeq DNA:
NG_009245
NT_016354
UniProtKB:
BMR1B_HUMAN (O00238)
Ensembl:
ENSG00000138696
GenAtlas:
BMPR1B
GeneCard:
BMPR1B
MutDB:
BMPR1B
ALFRED:
LO003222J
HuGE:
BMPR1B
Comparative Toxicogenomics Database:
658
ModBase:
O00238
HumanCyc Gene:
HS06538
HGNC:
1077

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