Gene:
ADK
adenosine kinase

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for ADK

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs10824095
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  adenosine 5'-phosphotransferase
Alternate Symbols:  AK
PharmGKB Accession Id: PA24579

Details

Cytogenetic Location: chr10 : q22.2 - q22.2
GP mRNA Boundary: chr10 : 75910943 - 76469061
GP Gene Boundary: chr10 : 75900943 - 76472061
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Schematic representation of abacavir metabolism and mechanism of action. The potential mechanism of an abacavir hypersensitivity reaction is also shown.
  1. Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
    Diagrammatic representation of a non-tissue specific cancer cell displaying candidate genes involved in the metabolism and action of thiopurines.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
abacavir
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
azathioprine
Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
antimetabolites

Curated Information ?

Publications related to ADK: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine. Inflammatory bowel diseases. 2015. Lee Mi-Na, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation. Biochemical pharmacology. 1999. Hatse S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Identification and isolation on a large scale of guanylate kinase from human erythrocytes. Effects of monophosphate nucleotides of purine analogs. Biochemical pharmacology. 1971. Agarwal R P, et al. PubMed

LinkOuts

NCBI Gene:
132
OMIM:
102750
UCSC Genome Browser:
NM_001123
RefSeq RNA:
NM_001123
NM_001202449
NM_001202450
NM_006721
RefSeq Protein:
NP_001114
NP_001189378
NP_001189379
NP_006712
RefSeq DNA:
NT_030059
UniProtKB:
ADK_HUMAN (P55263)
Q5JQ10_HUMAN (Q5JQ10)
Ensembl:
ENSG00000156110
GenAtlas:
ADK
GeneCard:
ADK
MutDB:
ADK
ALFRED:
LO001793U
HuGE:
ADK
Comparative Toxicogenomics Database:
132
ModBase:
P55263
HumanCyc Gene:
HS08097
HGNC:
257

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