Gene:
ADAM22
ADAM metallopeptidase domain 22

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
Alternate Symbols:  MDC2
PharmGKB Accession Id: PA24518

Details

Cytogenetic Location: chr7 : q21.12 - q21.12
GP mRNA Boundary: chr7 : 87563566 - 87832204
GP Gene Boundary: chr7 : 87553566 - 87835204
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to ADAM22: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association study of serious blistering skin rash caused by drugs. The pharmacogenomics journal. 2011. Shen Y, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science (New York, N.Y.). 2006. Fukata Yuko, et al. PubMed

LinkOuts

NCBI Gene:
53616
OMIM:
603709
UCSC Genome Browser:
NM_004194
RefSeq RNA:
NM_004194
NM_016351
NM_021721
NM_021722
NM_021723
RefSeq Protein:
NP_004185
NP_057435
NP_068367
NP_068368
NP_068369
MutDB:
ADAM22
ALFRED:
LO024201J
HuGE:
ADAM22
ModBase:
Q9P0K1
HumanCyc Gene:
HS00239
HGNC:
201

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