Gene:
ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.
PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
List of all variant annotations for ABO
|
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs495828 | NC_000009.11:g.136154867G=, NC_000009.11:g.136154867G>T, NC_000009.12:g.133279294T>G, NW_003315925.1:g.105388T=, NW_003315925.1:g.105388T>G, NW_009646201.1:g.105388T>G, rs60651416 |
G > T
|
SNP | |||
| rs8176740 | NC_000009.11:g.136131472A>T, NC_000009.12:g.133256085A>T, NG_006669.1:g.21583T>A, NM_020469.2:c.646T>A, NP_065202.2:p.Phe216Ile, NW_009646201.1:g.82178A>T, XM_005276848.1:c.643T>A, XM_005276849.1:c.589T>A, XM_005276850.1:c.223T>A, XM_005276851.1:c.223T>A, XM_005276852.1:c.223T>A, XP_005276905.1:p.Phe215Ile, XP_005276906.1:p.Phe197Ile, XP_005276907.1:p.Phe75Ile, XP_005276908.1:p.Phe75Ile, XP_005276909.1:p.Phe75Ile |
A > T
|
SNP |
F216I
|
||
| rs8176746 | NC_000009.11:g.136131322G>T, NC_000009.12:g.133255935G>T, NG_006669.1:g.21733C>A, NM_020469.2:c.796C>A, NP_065202.2:p.Leu266Met, NW_009646201.1:g.82028G>T, XM_005276848.1:c.793C>A, XM_005276849.1:c.739C>A, XM_005276850.1:c.373C>A, XM_005276851.1:c.373C>A, XM_005276852.1:c.373C>A, XP_005276905.1:p.Leu265Met, XP_005276906.1:p.Leu247Met, XP_005276907.1:p.Leu125Met, XP_005276908.1:p.Leu125Met, XP_005276909.1:p.Leu125Met, rs386615834, rs52812928, rs58313875 |
G > T
|
SNP |
L266M
|
Overview
| Alternate Names: | None |
|---|---|
| Alternate Symbols: | A3GALNT; A3GALT1 |
| PharmGKB Accession Id: | PA24415 |
Details
| Cytogenetic Location: | chr9 : q34.2 - q34.2 |
|---|---|
| GP mRNA Boundary†: | chr9 : 136130563 - 136150630 |
| GP Gene Boundary†: | chr9 : 136127563 - 136160630 |
| Strand: | minus |
Visualization
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.
View on UCSC BrowserCurated Information ?
| Evidence | Drug Class |
|---|---|
| Ace Inhibitors, Plain |
Publications related to ABO: 5
|
Could personalized management of menopause based on genomics become a reality?. Pharmacogenomics. 2016. Moyer Ann M, et al.
|
| Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension. Pharmacogenetics and genomics. 2014. Luo Jian-Quan, et al.
|
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| Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes. Pharmacogenetics and genomics. 2011. Mas Sergi, et al.
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| A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. The pharmacogenomics journal. 2010. Chung C-M, et al.
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Distribution of ABO and Rh blood groups in patients with HELLP syndrome. Archives of gynecology and obstetrics. 2002. Sezik M, et al.
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