Gene:
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for PTGS1

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs10306114 NC_000009.11:g.125132522A>G, NC_000009.12:g.122370243A>G, NG_032900.1:g.4294A>G, NM_000962.3:c.-842A>G, NM_001271164.1:c.-842A>G, NM_001271166.1:c.-920A>G, NM_001271367.1:c.-1140A>G, NM_001271368.1:c.-890A>G, NM_080591.2:c.-842A>G, XM_005252104.1:c.-890A>G, XM_005252105.1:c.-1139A>G, XM_005252105.2:c.-1139A>G, XM_005252106.1:c.-920A>G, XM_011518875.1:c.-890A>G, XM_011518876.1:c.-4752A>G
A > G
SNP
rs10306135 NC_000009.11:g.125137695A>T, NC_000009.12:g.122375416A>T, NG_032900.1:g.9467A>T, NM_000962.2:c.95-2483A>T, NM_000962.3:c.95-2483A>T, NM_001271164.1:c.95-2483A>T, NM_001271165.1:c.-262A>T, NM_001271166.1:c.-233-2483A>T, NM_001271367.1:c.-204-2512A>T, NM_001271368.1:c.20-2483A>T, NM_080591.2:c.95-2483A>T, XM_005252104.1:c.20-2483A>T, XM_005252105.1:c.20-2483A>T, XM_005252105.2:c.20-2483A>T, XM_005252106.1:c.-233-2483A>T, XM_011518875.1:c.20-2483A>T, XM_011518876.1:c.-262A>T
A > T
SNP
rs12353214 NC_000009.11:g.125161870C>T, NC_000009.12:g.122399591C>T
C > T
SNP
rs1236913 NC_000009.11:g.125133479T>C, NC_000009.12:g.122371200T>C, NG_032900.1:g.5251T>C, NM_000962.2:c.22T>C, NM_000962.3:c.22T>C, NM_001271164.1:c.22T>C, NM_001271166.1:c.-306T>C, NM_001271367.1:c.-277T>C, NM_001271368.1:c.-276T>C, NM_080591.2:c.22T>C, NP_000953.2:p.Trp8Arg, NP_001258093.1:p.Trp8Arg, NP_542158.1:p.Trp8Arg, XM_005252104.1:c.-276T>C, XM_005252105.1:c.-276T>C, XM_005252105.2:c.-276T>C, XM_005252106.1:c.-306T>C, XM_011518875.1:c.-276T>C, XM_011518876.1:c.-4138T>C, rs17856849, rs3842786, rs52820369, rs60505803
T > C
SNP
W8R
rs1330344
C > T
SNP
rs3842787 NC_000009.11:g.125133507C>T, NC_000009.12:g.122371228C>T, NG_032900.1:g.5279C>T, NM_000962.2:c.50C>T, NM_000962.3:c.50C>T, NM_001271164.1:c.50C>T, NM_001271166.1:c.-278C>T, NM_001271367.1:c.-249C>T, NM_001271368.1:c.-248C>T, NM_080591.2:c.50C>T, NP_000953.2:p.Pro17Leu, NP_001258093.1:p.Pro17Leu, NP_542158.1:p.Pro17Leu, XM_005252104.1:c.-248C>T, XM_005252105.1:c.-248C>T, XM_005252105.2:c.-248C>T, XM_005252106.1:c.-278C>T, XM_011518875.1:c.-248C>T, XM_011518876.1:c.-4110C>T
C > T
SNP
P17L
rs5788 NC_000009.11:g.125143792C>A, NC_000009.12:g.122381513C>A, NG_032900.1:g.15564C>A, NM_000962.2:c.639C>A, NM_000962.3:c.639C>A, NM_001271164.1:c.495C>A, NM_001271165.1:c.312C>A, NM_001271166.1:c.312C>A, NM_001271367.1:c.312C>A, NM_001271368.1:c.564C>A, NM_080591.2:c.639C>A, NP_000953.2:p.Gly213=, NP_001258093.1:p.Gly165=, NP_001258094.1:p.Gly104=, NP_001258095.1:p.Gly104=, NP_001258296.1:p.Gly104=, NP_001258297.1:p.Gly188=, NP_542158.1:p.Gly213=, XM_005252104.1:c.564C>A, XM_005252105.1:c.564C>A, XM_005252105.2:c.564C>A, XM_005252106.1:c.312C>A, XM_011518875.1:c.564C>A, XM_011518876.1:c.312C>A, XP_005252161.1:p.Gly188=, XP_005252162.1:p.Gly188=, XP_005252163.1:p.Gly104=, XP_011517177.1:p.Gly188=, XP_011517178.1:p.Gly104=, rs2229250, rs3842793, rs4134741, rs4987006, rs57161162
C > A
SNP
G213G
rs5789 NC_000009.11:g.125143973C>A, NC_000009.12:g.122381694C>A, NG_032900.1:g.15745C>A, NM_000962.2:c.709C>A, NM_000962.3:c.709C>A, NM_001271164.1:c.565C>A, NM_001271165.1:c.382C>A, NM_001271166.1:c.382C>A, NM_001271367.1:c.382C>A, NM_001271368.1:c.634C>A, NM_080591.2:c.709C>A, NP_000953.2:p.Leu237Met, NP_001258093.1:p.Leu189Met, NP_001258094.1:p.Leu128Met, NP_001258095.1:p.Leu128Met, NP_001258296.1:p.Leu128Met, NP_001258297.1:p.Leu212Met, NP_542158.1:p.Leu237Met, XM_005252104.1:c.634C>A, XM_005252105.1:c.634C>A, XM_005252105.2:c.634C>A, XM_005252106.1:c.382C>A, XM_011518875.1:c.634C>A, XM_011518876.1:c.382C>A, XP_005252161.1:p.Leu212Met, XP_005252162.1:p.Leu212Met, XP_005252163.1:p.Leu128Met, XP_011517177.1:p.Leu212Met, XP_011517178.1:p.Leu128Met, rs3842796, rs4987007, rs57008519
C > A
SNP
L237M
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  COX1; PGHS-1; PTGHS
PharmGKB Accession Id: PA24346

Details

Cytogenetic Location: chr9 : q32 - q33.3
GP mRNA Boundary: chr9 : 125132809 - 125157982
GP Gene Boundary: chr9 : 125122809 - 125160982
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Celecoxib Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of celecoxib and candidate genes interacting with celecoxib and involved in the regulation of cell cycle, apoptosis and angiogenesis by celecoxib.
  1. Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Etoposide cellular disposition and effects.
  1. Ibuprofen Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of ibuprofen (IBU).
  1. Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Effects of antiplatelet drugs on platelet aggregation pathway.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to PTGS1: 31

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting. PloS one. 2016. Li Xiao-Qing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Celecoxib interferes to a limited extent with aspirin-mediated inhibition of platelets aggregation. British journal of clinical pharmacology. 2015. Ruzov Mark, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease. Pharmacogenomics. 2015. Ayuso Pedro, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of cyclooxygenases. Pharmacogenomics. 2015. Agúndez José A G, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients. European journal of clinical pharmacology. 2014. Gao Li-Chen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetic insights into migraine treatment in children. Pharmacogenomics. 2014. Gentile Giovanna, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction. International journal of cardiology. 2012. Verschuren Jeffrey J W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1. Pharmacogenetics and genomics. 2012. Liu Wen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of drugs withdrawn from the market. Pharmacogenomics. 2012. Zhang Wei, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. The American journal of cardiology. 2010. St Germaine Christine G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics in cardiovascular antithrombotic therapy. Journal of the American College of Cardiology. 2009. Marín Francisco, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
COX-1 and vascular disease. Clinical pharmacology and therapeutics. 2009. Vanhoutte P M. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genetics of antiplatelet drug resistance. Clinical genetics. 2009. Feher G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Antiplatelet drug 'resistance'. Part 1: mechanisms and clinical measurements. Nature reviews. Cardiology. 2009. Sweeny Joseph M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. Thrombosis and haemostasis. 2009. Pettinella Caterina, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. Genomics. 2009. Yoshida Tetsuro, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. Clinical pharmacology and therapeutics. 2008. Lee C R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of platelet responsiveness to aspirin. Pharmacogenomics. 2007. Faraday Nauder, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007. Ito Noriyuki, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. Pharmacogenomics. 2007. Li Qing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation. 2007. Faraday Nauder, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation. 2007. Maree Andrew O, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275). The Annals of thoracic surgery. 2007. Lim Eric, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The pharmacogenetics of antiplatelet drugs. Current opinion in investigational drugs (London, England : 2000). 2007. Marín Francisco, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenetics and genomics. 2007. Lee Craig R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology. 2006. Fries Susanne, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer research. 2006. Daikoku Takiko, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. Thrombosis and haemostasis. 2006. Lepäntalo Aino, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cyclooxygenase-1 haplotype modulates platelet response to aspirin. Journal of thrombosis and haemostasis : JTH. 2005. Maree A O, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis. The Journal of biological chemistry. 1998. Parman T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. The Journal of biological chemistry. 1996. Smith W L, et al. PubMed

LinkOuts

NCBI Gene:
5742
OMIM:
176805
UCSC Genome Browser:
NM_000962
RefSeq RNA:
NM_000962
NM_080591
RefSeq Protein:
NP_000953
NP_542158
RefSeq DNA:
NT_008470
UniProtKB:
PGH1_HUMAN (P23219)
Ensembl:
ENSG00000095303
GenAtlas:
PTGS1
GeneCard:
PTGS1
MutDB:
PTGS1
ALFRED:
LO026365W
HuGE:
PTGS1
Comparative Toxicogenomics Database:
5742
ModBase:
P23219
HumanCyc Gene:
HS01815
HGNC:
9604

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