Gene:
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

Overview

Alternate Names:  None
Alternate Symbols:  GIRK1; KGA; Kir3.1
PharmGKB Accession Id: PA215

Details

Cytogenetic Location: chr2 : q24.1 - q24.1
GP mRNA Boundary: chr2 : 155555093 - 155714864
GP Gene Boundary: chr2 : 155545093 - 155717864
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Antiarrhythmic Pathway, Pharmacodynamics
    Pharmacodynamic pathway of antiarrhythmic drugs in a stylized cardiac myocyte.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
antiarrhythmics, class i and iii
No related diseases are available

Publications related to KCNJ3: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995. Krapivinsky G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 1993. Kubo Y, et al. PubMed

LinkOuts

NCBI Gene:
3760
OMIM:
601534
UCSC Genome Browser:
NM_002239
RefSeq RNA:
NM_002239
RefSeq Protein:
NP_002230
RefSeq DNA:
NT_005403
UniProtKB:
IRK3_HUMAN (P48549)
Ensembl:
ENSG00000162989
GenAtlas:
KCNJ3
GeneCard:
KCNJ3
MutDB:
KCNJ3
ALFRED:
LO026920T
HuGE:
KCNJ3
Comparative Toxicogenomics Database:
3760
ModBase:
P48549
HumanCyc Gene:
HS08768
IUPHAR Receptor:
Kir3.1 (434)
HGNC:
6264

Common Searches