Gene:
KCND3
potassium voltage-gated channel, Shal-related subfamily, member 3

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

Overview

Alternate Names:  SCA19; SCA22
Alternate Symbols:  KSHIVB; Kv4.3
PharmGKB Accession Id: PA210

Details

Cytogenetic Location: chr1 : p13.3 - p13.2
GP mRNA Boundary: chr1 : 112318444 - 112532147
GP Gene Boundary: chr1 : 112315444 - 112542147
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Antiarrhythmic Pathway, Pharmacodynamics
    Pharmacodynamic pathway of antiarrhythmic drugs in a stylized cardiac myocyte.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

No related genes are available

Curated Information ?

Curated Information ?

Publications related to KCND3: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genetics of pro-arrhythmic adverse drug reactions. British journal of clinical pharmacology. 2014. Petropoulou Evmorfia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. The pharmacogenomics journal. 2012. Ramirez A H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circulation research. 1996. Dixon J E, et al. PubMed

LinkOuts

NCBI Gene:
3752
OMIM:
605411
UCSC Genome Browser:
NM_004980
RefSeq RNA:
NM_004980
NM_172198
RefSeq Protein:
NP_004971
NP_751948
RefSeq DNA:
NT_032977
UniProtKB:
Q14D71_HUMAN (Q14D71)
KCND3_HUMAN (Q9UK17)
Ensembl:
ENSG00000171385
GenAtlas:
KCND3
GeneCard:
KCND3
MutDB:
KCND3
ALFRED:
LO004211I
HuGE:
KCND3
Comparative Toxicogenomics Database:
3752
ModBase:
Q9UK17
HumanCyc Gene:
HS10295
IUPHAR Receptor:
Kv4.3 (554)
HGNC:
6239

Common Searches