Gene:
GRK5
G protein-coupled receptor kinase 5

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for GRK5

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs2230345 NC_000010.10:g.121086097A>T, NC_000010.11:g.119326585A>T, NM_005308.2:c.122A>T, NP_005299.1:p.Gln41Leu, XM_005269707.1:c.122A>T, XM_005269708.1:c.53-54230A>T, XP_005269764.1:p.Gln41Leu, rs17098707, rs45630571, rs52829401
A > T
SNP
Q41L
rs915120 NC_000010.10:g.121190113T>C, NC_000010.11:g.119430601T>C, NM_005308.2:c.597+163T>C, XM_005269707.1:c.597+163T>C, XM_005269708.1:c.501+163T>C, XM_005269709.1:c.306+163T>C, XM_011539699.1:c.-34+163T>C, XM_011540450.1:c.-2936A>G, rs57517220
T > C
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  GPRK5
Alternate Symbols:  None
PharmGKB Accession Id: PA180

Details

Cytogenetic Location: chr10 : q26.11 - q26.11
GP mRNA Boundary: chr10 : 120967197 - 121215131
GP Gene Boundary: chr10 : 120957197 - 121218131
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to GRK5: 11

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of heart failure: a systematic review. Pharmacogenomics. 2016. Mottet Fannie, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The future of pharmacogenetics in the treatment of heart failure. Pharmacogenomics. 2015. Anwar Mohamed Subhan, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. The pharmacogenomics journal. 2012. Ji Y, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic tailoring of pharmacotherapy in heart failure: optimize the old, while we wait for something new. Journal of cardiac failure. 2012. Talameh Jasmine A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown. Pharmacogenomics. 2012. Lymperopoulos Anastasios, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cardiovascular Pharmacogenomics of Adrenergic Receptor Signaling: Clinical Implications and Future Directions. Clinical pharmacology and therapeutics. 2011. Johnson J A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Influence of gene-gene interactions on response to albuterol therapy. Pharmacogenomics. 2011. Moore Paul E. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients. Pharmacogenetics and genomics. 2010. Lobmeyer Maximilian T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans. Pharmacogenomics. 2009. Kurnik Daniel, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenetics and genomics. 2008. Wang Wayne C H, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature medicine. 2008. Liggett Stephen B, et al. PubMed

LinkOuts

NCBI Gene:
2869
OMIM:
600870
UCSC Genome Browser:
NM_005308
RefSeq RNA:
NM_005308
RefSeq Protein:
NP_005299
RefSeq DNA:
NT_030059
UniProtKB:
GRK5_HUMAN (P34947)
Ensembl:
ENSG00000198873
GenAtlas:
GRK5
GeneCard:
GRK5
MutDB:
GRK5
ALFRED:
LO008052P
HuGE:
GRK5
Comparative Toxicogenomics Database:
2869
ModBase:
P34947
HumanCyc Gene:
HS01823
HGNC:
4544

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