Gene:
CARTPT
CART prepropeptide

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for CARTPT

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs10515115 NC_000005.10:g.71716480T>A, NC_000005.9:g.71012307T>A, NG_015988.1:g.2318T>A, rs117462073, rs17358014
T > A
T > C
T > G
SNP
rs11575893 NC_000005.10:g.71719624C>T, NC_000005.9:g.71015451C>T, NG_015988.1:g.5462C>T, NM_004291.3:c.159+172C>T, rs59893632
C > T
SNP
rs16871471 NC_000005.10:g.71722730A>T, NC_000005.9:g.71018557A>T, NG_015988.1:g.8568A>T, rs57016258
A > T
SNP
rs3763153 NC_000005.10:g.71717820T>C, NC_000005.9:g.71013647T>C, NG_015988.1:g.3658T>C, NM_004291.3:c.-1474T>C, rs117489910, rs36223768, rs386585731, rs58334661
T > A
T > C
T > G
SNP
rs3857384 NC_000005.10:g.71718137C>T, NC_000005.9:g.71013964C>T, NG_015988.1:g.3975C>T, NM_004291.3:c.-1157C>T, rs36224097, rs59626536
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  cocaine and amphetamine regulated transcript
Alternate Symbols:  CART
PharmGKB Accession Id: PA162381084

Details

Cytogenetic Location: chr5 : q13.2 - q13.2
GP mRNA Boundary: chr5 : 71014990 - 71016875
GP Gene Boundary: chr5 : 71004990 - 71019875
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
ethanol
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
nicotine

Curated Information ?

Publications related to CARTPT: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Cocaine and amphetamine regulated transcript (CART) gene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence. Progress in neuro-psychopharmacology & biological psychiatry. 2010. Busto Amaya, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2002. Yamada K, et al. PubMed

LinkOuts

NCBI Gene:
9607
OMIM:
601665
602606
UCSC Genome Browser:
NM_004291
RefSeq RNA:
NM_004291
RefSeq Protein:
NP_004282
RefSeq DNA:
NG_015988
NT_006713
NT_113802
UniProtKB:
CART_HUMAN (Q16568)
Ensembl:
ENSG00000164326
GeneCard:
CARTPT
ALFRED:
LO036118T
HuGE:
CART
Comparative Toxicogenomics Database:
9607
HumanCyc Gene:
HS09061
HGNC:
24323

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