Gene:
TRMU
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  TRMT
Alternate Symbols:  FLJ10140; MTO2
PharmGKB Accession Id: PA142670701

Details

Cytogenetic Location: chr22 : q13.31 - q13.31
GP mRNA Boundary: chr22 : 46731298 - 46753237
GP Gene Boundary: chr22 : 46721298 - 46756237
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Deafness,nonsyndromic

Publications related to TRMU: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. American journal of human genetics. 2006. Guan Min-Xin, et al. PubMed

LinkOuts

NCBI Gene:
55687
OMIM:
580000
610230
613070
RefSeq RNA:
NM_018006
RefSeq Protein:
NP_060476
RefSeq DNA:
NG_012173
NT_011520
UniProtKB:
MTU1_HUMAN (O75648)
Ensembl:
ENSG00000100416
GeneCard:
TRMU
ALFRED:
LO017924X
HuGE:
TRMU
Comparative Toxicogenomics Database:
55687
ModBase:
O75648
HGNC:
25481

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