PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Symbols: ||DKFZp434H2111; FLJ45829; RIPK7; ROCO2|
|PharmGKB Accession Id:||PA134968052|
|Cytogenetic Location:||chr12 : q12 - q12|
|GP mRNA Boundary†:||chr12 : 40618813 - 40763087|
|GP Gene Boundary†:||chr12 : 40608813 - 40766087|
Publications related to LRRK2: 4
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- DG Dosing Guideline information is available
- DL Drug Label information is available
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||Parkinson's disease pharmacogenomics: new findings and perspectives. Pharmacogenomics. 2014. Schumacher-Schuh Artur F, et al.|
||Genomewide association study of leprosy. The New England journal of medicine. 2009. Zhang Fu-Ren, et al.|
||Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease. American journal of human genetics. 2008. Lautier Corinne, et al.|
||Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. European journal of human genetics : EJHG. 2006. Di Fonzo Alessio, et al.|