Gene:
TAAR6
trace amine associated receptor 6

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for TAAR6

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs4305746 NC_000006.11:g.132893765G>A, NC_000006.12:g.132572626G>A, NG_016544.1:g.7305G>A, rs61299378, rs7452939
G > A
SNP
rs7772821 NC_000006.11:g.132892506T>G, NC_000006.12:g.132571367T>G, NG_016544.1:g.6046T>G, NM_175067.1:c.*8T>G, rs58161682
T > C
T > G
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  TRAR4
Alternate Symbols:  TA4
PharmGKB Accession Id: PA134881141

Details

Cytogenetic Location: chr6 : q23.2 - q23.2
GP mRNA Boundary: chr6 : 132891461 - 132892498
GP Gene Boundary: chr6 : 132881461 - 132895498
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
aripiprazole
Evidence Drug Class
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
corticosteroids

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Asthma
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Schizophrenia

Publications related to TAAR6: 2

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients. Pharmacogenetics and genomics. 2015. Chang Hun Soo, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Influence of TAAR6 polymorphisms on response to aripiprazole. Progress in neuro-psychopharmacology & biological psychiatry. 2009. Serretti Alessandro, et al. PubMed

LinkOuts

NCBI Gene:
319100
OMIM:
603175
608923
RefSeq RNA:
NM_175067
RefSeq Protein:
NP_778237
RefSeq DNA:
NG_016544
NT_025741
UniProtKB:
TAAR6_HUMAN (Q96RI8)
Ensembl:
ENSG00000146383
GeneCard:
TAAR6
ALFRED:
LO008123O
HuGE:
TAAR6
Comparative Toxicogenomics Database:
319100
ModBase:
Q96RI8
HumanCyc Gene:
HS07345
IUPHAR Receptor:
TAAR6 (171)
HGNC:
20978

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