Gene:
PLCZ1
phospholipase C, zeta 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  NYD-SP27; PLCzeta
PharmGKB Accession Id: PA134875646

Details

Cytogenetic Location: chr12 : p12.3 - p12.3
GP mRNA Boundary: chr12 : 18836116 - 18890918
GP Gene Boundary: chr12 : 18833116 - 18900918
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Proton Pump Inhibitor Pathway, Pharmacodynamics
    Genes involved in the proton pump activation and trafficking.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

Curated Information ?

No related diseases are available

Publications related to PLCZ1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. The American journal of physiology. 1999. Wu H M, et al. PubMed

LinkOuts

Entrez Gene:
89869
OMIM:
608075
RefSeq RNA:
NM_033123
RefSeq Protein:
NP_149114
RefSeq DNA:
AC_000055
AC_000144
NC_000012
NT_009714
NW_001838052
NW_925328
UniProtKB:
PLCZ1_HUMAN (Q86YW0)
Ensembl:
ENSG00000139151
GeneCard:
PLCZ1
ALFRED:
LO008528X
HuGE:
PLCZ1
Comparative Toxicogenomics Database:
89869
ModBase:
Q86YW0
HumanCyc Gene:
HS06584
HGNC:
19218

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